Cardiolipin
Chemical compound / From Wikipedia, the free encyclopedia
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Cardiolipin (IUPAC name 1,3-bis(sn-3’-phosphatidyl)-sn-glycerol, "sn" designating stereospecific numbering) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition. It can also be found in the membranes of most bacteria. The name "cardiolipin" is derived from the fact that it was first found in animal hearts. It was first isolated from the beef heart in the early 1940s by Mary C. Pangborn.[1] In mammalian cells, but also in plant cells,[2][3] cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane, where it is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism.
General chemical structure of cardiolipins, where R1-R4 are variable fatty acid chains | |
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IUPAC name
1,3-bis(sn-3’-phosphatidyl)-sn-glycerol | |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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