Bedaquiline
Medication used to treat tuberculosis / From Wikipedia, the free encyclopedia
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Bedaquiline, sold under the brand name Sirturo, is a medication used for the treatment of active tuberculosis.[1] Specifically, it is used to treat multi-drug-resistant tuberculosis along with other medications for tuberculosis.[1][8][9] It is taken by mouth.[3]
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Trade names | Sirturo |
Other names | Bedaquiline fumarate,[1] TMC207,[2] R207910, AIDS222089 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a613022 |
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Routes of administration | By mouth |
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Protein binding | >99.9%[6] |
Metabolism | Liver, by CYP3A4[7] |
Elimination half-life | 5.5 months[7] |
Excretion | fecal[7] |
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Formula | C32H31BrN2O2 |
Molar mass | 555.516 g·mol−1 |
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Common side effects include nausea, joint pains, headaches, and chest pain.[1] Serious side effects include QT prolongation, liver dysfunction, and an increased risk of death.[1] While harm during pregnancy has not been found, it has not been well studied in this population.[10] It is in the diarylquinoline antimycobacterial class of medications.[1] It works by blocking the ability of M. tuberculosis to make adenosine 5'-triphosphate (ATP).[1]
Bedaquiline was approved for medical use in the United States in 2012.[1] It is on the World Health Organization's List of Essential Medicines.[11]