Acetyl-CoA carboxylase
Enzyme that regulates the metabolism of fatty acids / From Wikipedia, the free encyclopedia
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Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme (EC 6.4.1.2) that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes and in the chloroplasts of most plants and algae, whereas it is a large, multi-domain enzyme in the cytoplasm of most eukaryotes. The most important function of ACC is to provide the malonyl-CoA substrate for the biosynthesis of fatty acids.[1] The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification. The human genome contains the genes for two different ACCs[2]—ACACA[3] and ACACB.[4]
acetyl-CoA carboxylase | |||||||||
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Identifiers | |||||||||
EC no. | 6.4.1.2 | ||||||||
CAS no. | 9023-93-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Acetyl-CoA carboxylase alpha | |||||||
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Identifiers | |||||||
Symbol | ACACA | ||||||
Alt. symbols | ACAC, ACC1, ACCA | ||||||
NCBI gene | 31 | ||||||
HGNC | 84 | ||||||
OMIM | 601557 | ||||||
RefSeq | NM_198839 | ||||||
UniProt | Q13085 | ||||||
Other data | |||||||
EC number | 6.4.1.2 | ||||||
Locus | Chr. 17 q21 | ||||||
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Acetyl-CoA carboxylase beta | |||||||
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Identifiers | |||||||
Symbol | ACACB | ||||||
Alt. symbols | ACC2, ACCB | ||||||
NCBI gene | 32 | ||||||
HGNC | 85 | ||||||
OMIM | 200350 | ||||||
RefSeq | NM_001093 | ||||||
UniProt | O00763 | ||||||
Other data | |||||||
EC number | 6.4.1.2 | ||||||
Locus | Chr. 12 q24.1 | ||||||
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