preclinical

YQ. The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models. Oncotarget. 2016 Aug 2;7(31):49527-49538. doi:10

药物研发是指一旦通过药物发现确定了先导化合物，就将一种新的药物推向市场的过程。具體步驟包括对微生物和动物的临床前研究（英语：Preclinical development），申请监管機構批准（例如獲得美国食品药品监督管理局批准）後即可為研究性新药（英语：Investigational New

Cobra Venom Factor: Structure, Activity, And Therapeutic Efficacy In Preclinical Disease Models." Molecular Immunology 61.2 (2014): 191-203. Academic

百时美施贵宝否认沙格列汀会导致心血管疾病风险增加，并且称沙格列汀非常安全。[來源請求] Augeri D; et al. Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally

6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis. J. Med. Chem. 2017, 60, 10, 4212–4233