beta-secretase

Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane

memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid

亦有些基因突變，例如是A673T，就被認為能減低患上阿兹海默症的機會。這個突變位於 beta secretase cleavage site，理論上能經由減低beta C-Terminus fragment 而抑壓類澱粉蛋白的生成。證據顯示於試管內能減低40% 類澱粉蛋白生成。

的連結減少，並在年紀較大後受到老化相關過程的刺激，導致阿茲海默氏病中的神經元退化。該研究發現APP是DR6的一個配體，β-secretase（英语：beta-secretase）會切下的APP的N端片段產生N-APP（同樣的酵素也參與APP修飾為Aβ的過程），N-APP則會與死亡受體6（death

in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nature Medicine. July 2008, 14 (7): 723–30. PMC 2826895 . PMID 18587408