Wiskott–Aldrich syndrome

(CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. Proceedings of the National Academy of Sciences of the United

周围序列有助于确定小GTP酶的功能特异性，例如Rho亚家族常见的“插入环”，特别有助于与效应蛋白如IQGAP和WASP(Wiskott–Aldrich syndrome protein)结合。 通常，Ras家族负责细胞增殖：Rho用于细胞形态，Ran用于核运输，Rab和Arf用于囊泡运输。

Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. J. Biol

GTPases），它们通常存在于胞质中，但在某些条件下也可以在细胞膜中找到。当Cdc42被激活时，它可以与Wiskott-Aldrich综合征蛋白(WASp)（英语：Wiskott–Aldrich syndrome protein）家族受体，特别是N-WASp（英语：WASL

to loss of the motor neurons of the spinal cord and brainstem Wiskott–Aldrich syndrome; eczema, thrombocytopenia, immune deficiency, and bloody diarrhea