VCAM-1

VCAM-1（Vascular cell adhesion protein 1（I型血管細胞黏附蛋白）），又稱CD106，是一種細胞黏附蛋白，在人體內由VCAM-1基因編碼，屬於一種唾液酸糖蛋白^[5]。

VCAM-1
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 1IJ9、​1VCA、​1VSC
識別號
别名	VCAM1；, CD106, INCAM-100, vascular cell adhesion molecule 1
外部ID	OMIM：192225 MGI：98926 HomoloGene：838 GeneCards：VCAM1
基因位置（人类） 染色体 1號染色體[1] 基因座 1p21.2 起始 100,719,742 bp[1] 终止 100,739,045 bp[1]
基因位置（小鼠） 染色体 小鼠3号染色体[2] 基因座 3 G1|3 50.17 cM 起始 115,903,598 bp[2] 终止 115,923,337 bp[2]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • primary amine oxidase activity • integrin binding • cell adhesion molecule binding 細胞組分 • integral component of membrane • 高尔基体 • alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex • 膜 • 絲狀偽足 • 细胞膜 • apical part of cell • 微绒毛 • cell surface • 早期内吞体 • 内质网 • podosome • 肌膜 • 外排體 • external side of plasma membrane • 細胞外空間 • integral component of plasma membrane 生物學過程 • leukocyte cell-cell adhesion • response to ionizing radiation • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • response to hypoxia • response to nutrient • interferon-gamma-mediated signaling pathway • cellular response to tumor necrosis factor • response to nicotine • 老化 • response to zinc ion • extracellular matrix organization • amine metabolic process • response to lipopolysaccharide • 細胞粘附 • acute inflammatory response • positive regulation of T cell proliferation • membrane to membrane docking • regulation of immune response • leukocyte tethering or rolling • cell chemotaxis • B cell differentiation • cellular response to vascular endothelial growth factor stimulus • cell-matrix adhesion • viral process • response to ethanol • calcium-mediated signaling using intracellular calcium source • chronic inflammatory response • cell-cell adhesion • cytokine-mediated signaling pathway • heterotypic cell-cell adhesion • innervation • cardiac neuron differentiation • cell-cell adhesion in response to extracellular stimulus • cellular response to amyloid-beta Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	7412	22329
Ensembl	ENSG00000162692	ENSMUSG00000027962
UniProt	P19320	P29533
mRNA​序列	NM_080682 ​NM_001078 ​NM_001199834	NM_011693
蛋白序列	NP_001069 ​NP_001186763 ​NP_542413	NP_035823
基因位置​（UCSC）	Chr 1: 100.72 – 100.74 Mb	Chr 3: 115.9 – 115.92 Mb
PubMed​查找	[3]	[4]
維基數據
檢視/編輯人類 檢視/編輯小鼠

結構

VCAM-1含有6個或7個免疫球蛋白結構域，屬於免疫球蛋白蛋白超家族（英语：Protein superfamily）（IgSF）。於人體內存在兩個由可變剪接產生的轉錄本^[6]。

功能與分佈

VCAM-1參與淋巴細胞—內皮細胞間黏附過程和細胞間信號識別過程，能在免疫應答中促進淋巴細胞向炎症區遷移^[7]。淋巴細胞、軟骨細胞等細胞中都含有VCAM-1，血管內皮細胞在受到細胞因子刺激後也會表達VCAM-1蛋白^[6][8]。一些間充質幹細胞亞群細胞表面表達CD106（VCAM-1）^[9]。

參考

1. GRCh38: Ensembl release 89: ENSG00000162692 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027962 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, Gimbrone MA Jr, Collins T. The human VCAM1 gene is assigned to chromosome 1p31-p32. Cytogenet. Cell Genet. 1991, 58: 1852. doi:10.1159/000133735.
6. Entrez Gene: VCAM1 vascular cell adhesion molecule 1.
7. VCAM1. Uniprot. [2018-01-10]. （原始内容存档于2017-10-03）.
8. Kienzle G.; von Kempis J. Vascular cell adhesion molecule 1 (CD106) on primary human articular chondrocytes: functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 (CD54) and very late activation antigen 2. Arthritis Rheum. 1998 Jul;41(7):1296-305.
9. ZX Yang; et al. CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties. PLoS One. 2013;8(3):e59354. 引文格式1维护：显式使用等标签 (link)