MASP-1

甘露糖结合凝集素丝氨酸蛋白酶1 （Mannan-binding lectin serine protease 1，也被称为 甘露糖相关丝氨酸蛋白酶1，mannose-associated serine protease 1，缩写MASP-1）是由人类基因 MASP1 编码的一种酶。^[1][2][3]

Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 3DEM, 3GOV, 4AQB, 4DJZ, 4IGD, 4IW4, 4KKD
标识
代号	MASP1; 3MC1; CRARF; CRARF1; MAP1; MASP; MASP3; MAp44; PRSS5; RaRF
扩展标识	遗传学：600521 同源基因：89143 GeneCards: MASP1 Gene
EC編號	3.4.21.-
基因本体论描述 分子功能 · serine-type endopeptidase activity · calcium ion binding · protein binding · peptidase activity · protein homodimerization activity · calcium-dependent protein binding 细胞成分 · extracellular region · extracellular space 生物过程 · complement activation, lectin pathway · proteolysis · receptor-mediated endocytosis · complement activation · innate immune response · negative regulation of complement activation Sources: Amigo / QuickGO
直系同源体
物种	人类	小鼠
Entrez	5648	n/a
Ensembl	ENSG00000127241	n/a
UniProt	P48740	n/a
mRNA序列	NM_001031849	n/a
蛋白序列	NP_001027019	n/a
基因位置	Chr 3: 187.22 – 187.29 Mb	n/a
PubMed查询	[1]	n/a
查 论 编

MASP-1参与补体系统的凝集素途径，负责的切割C4和C2形成C4b2a，作为C3-转化酶参与下一步的反应。^[4]

另见

• 甘露聚糖结合凝集素

参考文献

1. A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum. Biochemical and Biophysical Research Communications. Oct 1993, 196 (2): 1003–9. PMID 8240317. doi:10.1006/bbrc.1993.2349.
2. Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. International Immunology. Apr 1994, 6 (4): 665–9. PMID 8018603. doi:10.1093/intimm/6.4.665.
3. Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor).
4. Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Journal of Immunology. Sep 2000, 165 (5): 2637–42 [2016-11-24]. PMID 10946292. doi:10.4049/jimmunol.165.5.2637. （原始内容存档于2009-01-09）.

外部链接

• 醫學主題詞表（MeSH）：MASP+Proteases

MASP-1引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。