CD132

CD132，又称为共用γ链（Common gamma chain，缩写γ_c)，白介素2受体γ亚基（interleukin-2 receptor subunit gamma，缩写IL-2RG）是一种细胞因子受体亚基，存在于至少六种不同的白介素受体中：包括IL-2、IL-4^[7]、IL-7^[8]、IL-9、IL-15^[9]和IL-21的受体。γ_c是I型细胞因子受体家族中的一种醣蛋白，表达于大部分的淋巴细胞群体，哺乳动物的此基因位于X染色体。

CD132
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 2B5I、​2ERJ、​3BPL、​3QAZ、​3QB7、​4GS7
識別號
别名	IL2RG；, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
外部ID	OMIM：308380 MGI：96551 HomoloGene：172 GeneCards：IL2RG
相關疾病
X性聯嚴重複合免疫缺乏症、​combined immunodeficiency, X-linked[1]
為以下藥物的標靶
denileukin diftitox[2]
基因位置（人类） 染色体 X染色體[3] 基因座 Xq13.1 起始 71,107,404 bp[3] 终止 71,112,108 bp[3]
基因位置（小鼠） 染色体 小鼠X染色体[4] 基因座 X D|X 43.9 cM 起始 100,307,984 bp[4] 终止 100,311,861 bp[4]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • interleukin-7 receptor activity • interleukin-2 receptor activity • 血浆蛋白结合 • cytokine receptor activity • interleukin-4 receptor activity • interleukin-2 binding • cytokine binding • interleukin-15 receptor activity 細胞組分 • integral component of membrane • 膜 • 细胞膜 • integral component of plasma membrane • external side of plasma membrane • 核内体 • 细胞质基质 • cell surface • receptor complex 生物學過程 • MAPK cascade • 免疫反应 • viral process • 訊息傳遞 • interleukin-2-mediated signaling pathway • interleukin-4-mediated signaling pathway • interleukin-7-mediated signaling pathway • interleukin-15-mediated signaling pathway • interleukin-9-mediated signaling pathway • 分子功能调控 • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway • positive regulation of phagocytosis Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3561	16186
Ensembl	ENSG00000147168	ENSMUSG00000031304
UniProt	P31785	P34902
mRNA​序列	NM_000206	NM_013563 ​NM_001308535
蛋白序列	NP_000197	NP_001295464 ​NP_038591
基因位置​（UCSC）	Chr X: 71.11 – 71.11 Mb	Chr X: 100.31 – 100.31 Mb
PubMed​查找	[5]	[6]
維基數據
檢視/編輯人類 檢視/編輯小鼠

参考文献

1. 與CD132相關的疾病；在維基數據上查看/編輯參考.
2. 對Interleukin 2 receptor subunit gamma起作用的藥物；在維基數據上查看/編輯參考.
3. GRCh38: Ensembl release 89: ENSG00000147168 - Ensembl, May 2017
4. GRCm38: Ensembl release 89: ENSMUSG00000031304 - Ensembl, May 2017
5. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
7. Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. December 1993, 262 (5141): 1880–3. PMID 8266078. doi:10.1126/science.8266078.
8. Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science. December 1993, 262 (5141): 1877–80. PMID 8266077. doi:10.1126/science.8266077.
9. Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. August 1995, 14 (15): 3654–63. PMC 394440 . PMID 7641685.

延伸阅读

• Buckley RH. Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Annu Rev Immunol. 2004, 22: 625–55. PMID 15032591. doi:10.1146/annurev.immunol.22.012703.104614.
• Kalman L, Lindegren ML, Kobrynski L, Vogt R, Hannon H, Howard JT, Buckley R. Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: HuGE review. Genet Med. 2004, 6 (1): 16–26. PMID 14726805. doi:10.1097/01.GIM.0000105752.80592.A3.
• Ellery JM, Nicholls PJ. Alternate signalling pathways from the interleukin-2 receptor. Cytokine Growth Factor Rev. 2002, 13 (1): 27–40. PMID 11750878. doi:10.1016/S1359-6101(01)00023-5.
• Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K. Cloning of the gamma chain of the human IL-2 receptor. Science. July 1992, 257 (5068): 379–82. PMID 1631559. doi:10.1126/science.1631559.
• Burton J, Goldman CK, Rao P, Moos M, Waldmann TA. Association of intercellular adhesion molecule 1 with the multichain high-affinity interleukin 2 receptor. Proc. Natl. Acad. Sci. U.S.A. September 1990, 87 (18): 7329–33. PMC 54737 . PMID 1976256. doi:10.1073/pnas.87.18.7329.
• Oyaizu N, Chirmule N, Kalyanaraman VS, Hall WW, Pahwa R, Shuster M, Pahwa S. Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA. Proc. Natl. Acad. Sci. U.S.A. March 1990, 87 (6): 2379–83. PMC 53690 . PMID 2315327. doi:10.1073/pnas.87.6.2379.
• Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM. Lymphocyte activation by HIV-1 envelope glycoprotein. Nature. September 1988, 335 (6189): 445–8. PMID 2843775. doi:10.1038/335445a0.
• Bamborough P, Hedgecock CJ, Richards WG. The interleukin-2 and interleukin-4 receptors studied by molecular modelling. Structure. 1995, 2 (9): 839–51. PMID 7529123. doi:10.1016/S0969-2126(94)00085-9.
• Clark PA, Lester T, Genet S, Jones AM, Hendriks R, Levinsky RJ, Kinnon C. Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis. Hum. Genet. October 1995, 96 (4): 427–32. PMID 7557965. doi:10.1007/BF00191801.
• Pepper AE, Buckley RH, Small TN, Puck JM. Two mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiency. Am. J. Hum. Genet. September 1995, 57 (3): 564–71. PMC 1801277 . PMID 7668284.
• Ohbo K, Takasawa N, Ishii N, Tanaka N, Nakamura M, Sugamura K. Functional analysis of the human interleukin 2 receptor gamma chain gene promoter. J. Biol. Chem. March 1995, 270 (13): 7479–86. PMID 7706294. doi:10.1074/jbc.270.13.7479.
• Puck JM, Pepper AE, Bédard PM, Laframboise R. Female germ line mosaicism as the origin of a unique IL-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency. J. Clin. Invest. February 1995, 95 (2): 895–9. PMC 295580 . PMID 7860773. doi:10.1172/JCI117740.
• DiSanto JP, Rieux-Laucat F, Dautry-Varsat A, Fischer A, de Saint Basile G. Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells. Proc. Natl. Acad. Sci. U.S.A. September 1994, 91 (20): 9466–70. PMC 44833 . PMID 7937790. doi:10.1073/pnas.91.20.9466.
• Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID. Science. November 1994, 266 (5187): 1042–5. PMID 7973658. doi:10.1126/science.7973658.
• Ishii N, Asao H, Kimura Y, Takeshita T, Nakamura M, Tsuchiya S, Konno T, Maeda M, Uchiyama T, Sugamura K. Impairment of ligand binding and growth signaling of mutant IL-2 receptor gamma-chains in patients with X-linked severe combined immunodeficiency. J. Immunol. August 1994, 153 (3): 1310–7. PMID 8027558.
• Johnson K, Choi Y, Wu Z, Ciardelli T, Granzow R, Whalen C, Sana T, Pardee G, Smith K, Creasey A. Soluble IL-2 receptor beta and gamma subunits: ligand binding and cooperativity. Eur. Cytokine Netw. 1994, 5 (1): 23–34. PMID 8049354.
• Markiewicz S, Subtil A, Dautry-Varsat A, Fischer A, de Saint Basile G. Detection of three nonsense mutations and one missense mutation in the interleukin-2 receptor gamma chain gene in SCIDX1 that differently affect the mRNA processing. Genomics. May 1994, 21 (1): 291–3. PMID 8088810. doi:10.1006/geno.1994.1265.
• Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, Sugamura K. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science. December 1993, 262 (5141): 1874–7. PMID 8266076. doi:10.1126/science.8266076.

外部链接

• 醫學主題詞表（MeSH）：Interleukin+Receptor+Common+gamma+Subunit