2-羟基异己酸

2-羟基异己酸（英語：2-Hydroxyisocaproic acid，缩写HICA，也称为 闪白酸，英語：leucic acid）是支链氨基酸亮氨酸的代谢产物^[1]。HICA经常作为一种所谓的肌肉增强剂出售^[2]，同时也能作为杀真菌剂使用^[2]。HICA能够增加诱导性肌肉萎缩大鼠的蛋白质生物合成和肌肉质量^[3]。

2-羟基异己酸
IUPAC名 2-Hydroxy-4-methylpentanoic acid
别名	2-羟基-4-甲基戊酸、闪白酸
识别
CAS号	498-36-2  Y
PubChem	92779
ChemSpider	83753
SMILES	CC(C)CC(C(=O)O)O
InChI	1/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9)
InChIKey	LVRFTAZAXQPQHI-UHFFFAOYAQ
性质
化学式	C6H12O3
摩尔质量	132.16 g·mol−1
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

参考资料

1. Investigation of the presence of β-hydroxy-β-methylbutyric acid and α-hydroxyisocaproic acid in bovine whole milk and fermented dairy products by a validated liquid chromatography-mass spectrometry method.. Journal of Agricultural and Food Chemistry. February 2014, 62 (7): 1506–11. PMID 24495238. doi:10.1021/jf500026s.
2. 2-hydroxyisocaproic acid is fungicidal for Candida and Aspergillus species.. Mycoses. April 2014, 57 (4): 214–21. PMID 24125484. doi:10.1111/myc.12145.
3. Chronic α-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy.. American Journal of Physiology. August 2013, 305 (3): E416–28. PMID 23757407. doi:10.1152/ajpendo.00618.2012.