非洲刺毛鼠屬（學名：Acomys），哺乳綱、囓齒目、鼠科一属的物种，非洲攀鼠亞科四個屬之一[1]。外形上與小鼠属（Mus）物種相似，非洲刺毛鼠屬物種的體型細小，有無毛的鳞尾，不過遺傳學證據表明本屬物種與沙鼠的關係更為密切[2][3]。
本屬包括以下各物種：
- Western Saharan spiny mouse, Acomys airensis
- 开罗刺鼠 Acomys cahirinus
- Chudeau's spiny mouse, Acomys chudeaui
- Asia Minor spiny mouse, Acomys cilicicus
- Gray spiny mouse, Acomys cineraceus
- 東方刺毛鼠 Acomys dimidiatus
- Fiery spiny mouse, Acomys ignitus
- Johan's spiny mouse, Acomys johannis
- Kemp's spiny mouse, Acomys kempi
- Louise's spiny mouse, Acomys louisae
- 小非洲刺毛鼠 Acomys minous
- Mullah spiny mouse, Acomys mullah
- Acomys muzei
- Cyprus spiny mouse, Acomys nesiotes
- Acomys ngurui
- Percival's spiny mouse, Acomys percivali
- 金刺鼠 Acomys russatus
- Seurat's spiny mouse, Acomys seurati
- Southern African spiny mouse, Acomys spinosissimus
- Cape spiny mouse, Acomys subspinosus
- Wilson's spiny mouse, Acomys wilsoni
Chevret, P.; Denys, C.; Jaeger, J.-J.; Michaux, J; Catzeflis, F. M. Molecular evidence that the spiny mouse (Acomys) is more closely related to gerbils (Gerbillinae) than to the true mice (Murinae). Proceedings of the National Academy of Sciences (USA). 1993, 90: 3433–3436 （英语）.
