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蘇糖核酸（英語：Threose nucleic acid，缩写：TNA）是一種與DNA和RNA相似的化學物質，但組成物有所不同。地球上已知生物並未發現體內有此物質。
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TNA的骨架是由重複排列的蘇糖（threose）單位，經由磷酸酯鍵連結而成。在實驗室中，可利用DNA聚合酶合成出DNA與TNA的混合長鏈。
- Was simple TNA the first nucleic acid on Earth to carry a genetic code? （页面存档备份，存于互联网档案馆） - New scientist
- ORIGIN OF LIFE: A Simpler Nucleic Acid （页面存档备份，存于互联网档案馆） - Leslie Orgel
- Orgel, Leslie. A Simpler Nucleic Acid. Science. Nov 2000, 290 (5495): 1306 – 1307. doi:10.1126/science.290.5495.1306.
- Watt, Gregory. Modified nucleic acids on display. Nature Chemical Biology. Feb 2005 [2007-07-25]. doi:10.1038/nchembio005. （原始内容存档于2016-03-08）.
- Schoning, K; Scholz P; Guntha S; Wu X; Krishnamurthy R; Eschenmoser A. Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-(3'->2') oligonucleotide system.. Science. Nov 2000. PMID 11082060.
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