络丝蛋白

络丝蛋白（英語：Reelin）是一种分泌于细胞外基质的大型糖蛋白，用于在大脑的发育中通过细胞-细胞相互作用调控神经元的迁移和定位。

Reelin
络丝蛋白第三重复域的晶体结构[1]
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 2ddu, 2e26
标识
代号	RELN; LIS2; PRO1598; RL
扩展标识	遗传学：600514 鼠基因：103022 同源基因：3699 GeneCards: RELN Gene
EC編號	3.4.21.-
基因本体论描述 分子功能 · protein serine/threonine/tyrosine kinase activity · serine-type peptidase activity · metal ion binding · lipoprotein particle receptor binding · very-low-density lipoprotein particle receptor binding 细胞成分 · proteinaceous extracellular matrix · extracellular space · cytoplasm · dendrite 生物过程 · cell morphogenesis involved in differentiation · neuron migration · proteolysis · cell adhesion · axon guidance · central nervous system development · brain development · long-term memory · associative learning · glial cell differentiation · positive regulation of neuron projection development · positive regulation of phosphatidylinositol 3-kinase cascade · dendrite development · peptidyl-tyrosine phosphorylation · spinal cord patterning · ventral spinal cord development · hippocampus development · cerebral cortex tangential migration · positive regulation of TOR signaling cascade · positive regulation of CREB transcription factor activity · reelin-mediated signaling pathway · positive regulation of protein kinase activity · response to pain · positive regulation of peptidyl-tyrosine phosphorylation · regulation of behavior · regulation of synaptic transmission · positive regulation of small GTPase mediated signal transduction · positive regulation of synaptic transmission, glutamatergic · positive regulation of dendritic spine morphogenesis · positive regulation of protein tyrosine kinase activity · positive regulation of synapse maturation · N-methyl-D-aspartate receptor clustering · postsynaptic density protein 95 clustering · receptor localization to synapse · positive regulation of long-term synaptic potentiation · regulation of N-methyl-D-aspartate selective glutamate receptor activity · positive regulation of excitatory postsynaptic membrane potential · positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	5649	19699
Ensembl	ENSG00000189056	ENSMUSG00000042453
UniProt	P78509	Q60841
mRNA序列	NM_005045	NM_011261
蛋白序列	NP_005036	NP_035391
基因位置	Chr 7: 103.11 – 103.63 Mb	Chr 5: 21.88 – 22.34 Mb
PubMed查询	[1]	[2]
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参考文献

1. PDB 2ddu; Nogi T, Yasui N, Hattori M, Iwasaki K, Takagi J. Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography. EMBO J. August 2006, 25 (15): 3675–83. PMC 1538547 . PMID 16858396. doi:10.1038/sj.emboj.7601240.

Recommended reading

• The book: Fatemi, S. Hossein. Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. Berlin: Springer. 2008: 444 pages. ISBN 978-0-387-76760-4.
• A review: Förster E, Jossin Y, Zhao S, Chai X, Frotscher M, Goffinet AM. Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus. Eur. J. Neurosci. February 2006, 23 (4): 901–9. PMID 16519655. doi:10.1111/j.1460-9568.2006.04612.x.

外部链接

Articles, publications, webpages

• Gabriella D'Arcangelo. Rutgers University. [2008-08-23]. （原始内容存档于2008-07-25）. the scientist who discovered the reelin gene and protein
• Human RELN at WikiGenes

Figures and images

• Reelin gene expression in mice. Brain Gene Expression Map. St. Jude Children’s Research Hospital. [2008-08-23]. （原始内容存档于2005-01-23）.
• Schematic representation of signaling through the LDLR family members apoER2 and VLDL receptor. [2008-08-23].^{[永久失效連結]} – A figure from Beffert U, Stolt PC, Herz J. Functions of lipoprotein receptors in neurons. J. Lipid Res. March 2004, 45 (3): 403–9. PMID 14657206. doi:10.1194/jlr.R300017-JLR200.
• Proposed mechanism by which mouse RELN promoter regulate reelin gene expression. Proc. Natl. Acad. Sci. USA. [2008-08-23]. （原始内容存档于2007-12-25）. – A figure from Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A. Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc. Natl. Acad. Sci. U.S.A. August 2005, 102 (35): 12578–83. PMC 1194936 . PMID 16113080. doi:10.1073/pnas.0505394102.
• Corticogenesis in wild-type, reeler mutant and β1 deficient mice. [2008-08-23]. （原始内容存档于2007-12-24）. Pictorial rendition of the difference that the lack of reelin brings to the cortical structure – A figure from Magdaleno SM, Curran T. Brain development: integrins and the Reelin pathway. Curr. Biol. December 2001, 11 (24): R1032–5. PMID 11747842. doi:10.1016/S0960-9822(01)00618-2.
• Effects of human and naturally occurring mouse RELN mutations on the predicted protein. Nature Genetics. [2008-08-23]. （原始内容存档于2007-12-15）. A figure from Hong SE; Shugart YY; Huang DT; et al. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Nat. Genet. September 2000, 26 (1): 93–6. PMID 10973257. doi:10.1038/79246.
• MRI analysis of chromosome 7q22-linked lissencephaly with cerebellar hypoplasia. Nature Genetics. [2008-08-23]. （原始内容存档于2007-12-15）. – A figure from Hong et al.