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细球腔菌科（学名：Leptosphaeriaceae）为格孢菌目的一科真菌。
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本科包括以下属：[1]
- Acicuseptoria Quaedvl., Verkley & Crous, 2013
- 近小球腔菌属 Alloleptosphaeria Ariyawansa, Wanasinghe & K.D.Hyde, 2015
- Alloleptosphaeria clematidis Phukhams. & K.D.Hyde
- Alloleptosphaeria iridicola (Crous & Denman) Voglmayr
- 意大利近小球腔菌 Alloleptosphaeria italica Wanas., Camporesi, Ariyaw. & K.D.Hyde
- 香格里拉近小球腔菌 Alloleptosphaeria shangrilana Thiyagaraja, Tennakoon & K.D.Hyde, 2021[2]
- Angularia R.Xu, Phukhams. & Yu Li, 2022
- Angularia xanthoceratis R.Xu, Phukhams. & Yu Li, 2022
- Clisosporium Fr., 1819
- Clisosporium epimyces (Sacc. & Speg.) Kuntze, 1898，基异名：Coniothyrium epimyces Sacc. & Speg., 1878
- Dendroleptosphaeria Sousa da Câmara 1932
- Dendroleptosphaeria castaneicola Sousa da Câmara & Luz, 1939
- Heptameria Rehm & Thüm., 1879
- Heterospora (Boerema, Gruyter & Noordel.) Gruyter, Aveskamp & Verkley, 2012
- Heterosporicola Crous, 2017
- 细球腔菌属 Leptosphaeria Cesati & de Notaris, 1863
- Longiseptatispora L.W.Hou & Crous, 2020
- Mycotodea Kirschst.
- Neoleptosphaeria Ariyawansa & K.D.Hyde, 2015
- Ochraceocephala Voglmayr & Aiello, 2020
- Parahendersonia
- Paraleptosphaeria Gruyter, Aveskamp & Verkley
- Phyllophthalmaria
- Plenodomus Preuss
- 卓越孢属 Praeclarispora
- 蒿卓越孢 Praeclarispora artemisiae Doilom, W.Dong, K.D.Hyde & C.F.Liao
- Pseudoleptosphaeria Ariyaw. & K.D.Hyde, 2015
- Querciphoma Crous, 2017
- Sclerenchymomyces Phukhams. & K.D.Hyde, 2020
- Sclerodothis
- Subplenodomus Gruyter, Aveskamp & Verkley
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