巨蟹蛛科（Sparassidae），舊稱高腳蛛科（Heteropodidae），）屬於巨蟹蛛總科，之下包括多種體型較大的蜘蛛。其物種分布於世界各地暖帶及熱帶地區，目前已命名者超過一千種以上。
一隻 Isopeda villosa 正在褪去其外骨骼。
截至2019年4月 (2019-04)[update]，World Spider Catalog現時接受本科包括下列各個屬[1]：
- Adcatomus Karsch, 1880 — Venezuela, Peru
- Anaptomecus Simon, 1903 — Central America, South America
- Anchonastus Simon, 1898 — 喀麦隆, Congo
- Arandisa Lawrence, 1938 — Namibia
- Barylestis Simon, 1910 — 非洲, 亚洲, Europe
- Beregama Hirst, 1990 — 澳大利亚, Papua New Guinea
- Berlandia Lessert, 1921 — 东非
- Bhutaniella Jäger, 2000 — 亚洲
- Caayguara Rheims, 2010 — 巴西
- Carparachne Lawrence, 1962 — Namibia
- Cebrennus Simon, 1880 — 非洲, 亚洲, Malta
- Cerbalus Simon, 1897 — Israel, Jordan, Egypt
- Chrosioderma Simon, 1897 — Madagascar
- Clastes Walckenaer, 1837 — Indonesia, Papua New Guinea
- Curicaberis Rheims, 2015 — North America, Central America, Brazil
- Damastes Simon, 1880 — Madagascar, Mozambique, Seychelles
- Decaphora Franganillo, 1931 — North America, Caribbean, Central America, Colombia
- Defectrix Petrunkevitch, 1925 — Panama
- Delena Walckenaer, 1837 — 澳大利亚, 新西兰
- Dermochrosia Mello-Leitão, 1940 — Brazil
- Diminutella Rheims & Alayón, 2018 — Cuba
- 艾舞蛛属 Eusparassus Simon, 1903：分佈於亞洲、非洲、歐洲及南美洲的秘魯
- Exopalystes Hogg, 1914 — Papua New Guinea
- Geminia Thorell, 1897 — Myanmar
- 吉遁蛛属 Gnathopalystes Rainbow, 1899[2]：見於亞洲及大洋洲。
- Guadana Rheims, 2010 — Brazil, Peru, Ecuador
- 異足蛛屬 Heteropoda Latreille, 1804：見於大洋洲、亞洲、南美洲及希臘。
- Holconia Thorell, 1877 — Australia
- Irileka Hirst, 1998 — 澳大利亚
- Isopeda L. Koch, 1875 — 澳大利亚, Philippines, Papua New Guinea
- Isopedella Hirst, 1990 — 澳大利亚, Papua New Guinea, Indonesia
- Keilira Hirst, 1989 — 澳大利亚
- Leucorchestris Lawrence, 1962 — Angola, Namibia
- Macrinus Simon, 1887 — South America, Tobago, United States
- Martensopoda Jäger, 2006 — India
- May Jäger & Krehenwinkel, 2015 — Namibia, South Africa
- Megaloremmius Simon, 1903 — Madagascar
- 小遁蛛属 Micrommata Latreille, 1804：見於亞洲、非洲及歐洲的西班牙。
- Microrchestris Lawrence, 1962 — Namibia
- Neosparassus Hogg, 1903 — Australia
- Neostasina Rheims & Alayón, 2016 — Caribbean
- Nisueta Simon, 1880 — Sudan, Ethiopia, Tanzania
- Nolavia Kammerer, 2006 — Brazil
- Nonianus Simon, 1885 — South America, Algeria, Israel
- Nungara Pinto & Rheims, 2016 — Brazil, Ecuador
- Olios Walckenaer, 1837 — Asia, South America, Oceania, Africa, Central America, North America, Caribbean
- Orchestrella Lawrence, 1965 — Namibia
- Origes Simon, 1897 — Argentina, Peru, Ecuador
- Paenula Simon, 1897 — Ecuador
- Palystella Lawrence, 1928 — Namibia
- Palystes L. Koch, 1875 — Africa, India, Australia
- Panaretella Lawrence, 1937 — South Africa
- Pandercetes L. Koch, 1875 — 亚洲, Oceania
- Parapalystes Croeser, 1996 — 南非
- Pediana Simon, 1880 — Indonesia, Australia
- Pleorotus Simon, 1898 — Seychelles
- Polybetes Simon, 1897 — South America
- Prusias O. Pickard-Cambridge, 1892 — Brazil, Mexico, Panama
- Prychia L. Koch, 1875 — Papua New Guinea, Fiji, Philippines
- Pseudomicrommata Järvi, 1914 — Africa
- 伪遁蛛属 Pseudopoda Jäger, 2000，拟遁蛛属 — 亚洲
- Pseudosparianthis Simon, 1887 — South America, Central America, Saint Vincent and the Grenadines
- Quemedice Mello-Leitão, 1942 — Brazil, Argentina
- Remmius Simon, 1897 — 非洲
- Rhacocnemis Simon, 1897 — Seychelles
- Rhitymna Simon, 1897 — 亚洲, 非洲
- Sagellula Strand, 1942 — 日本, 中国
- Sampaiosia Mello-Leitão, 1930 — Brazil
- Sarotesius Pocock, 1898 — East Africa
- 华遁蛛属 Sinopoda Jäger, 1999 — 亚洲
- Sivalicus Dyal, 1957 — India
- 斯帕蛛属 Sparassus （？）
- Sparianthina Banks, 1929 — South America, Tobago, Central America
- Sparianthis Simon, 1880 — Colombia
- Spariolenus Simon, 1880 — 亚洲
- Staianus Simon, 1889 — Madagascar
- Stasina Simon, 1877 — South America, Gabon, 亚洲, Cuba
- Stasinoides Berland, 1922 — Ethiopia
- Stipax Simon, 1898 — Seychelles
- Strandiellum Kolosváry, 1934 — Papua New Guinea
- 塞蛛属 Thelcticopis Karsch, 1884 — Asia, Oceania, Africa
- Thomasettia Hirst, 1911 — Seychelles
- Tibellomma Simon, 1903 — Venezuela
- Tychicus Simon, 1880 — Philippines, Papua New Guinea, Indonesia
- Typostola Simon, 1897 — 澳大利亚, Papua New Guinea
- Uaiuara Rheims, 2013 — Panama, South America
- Vindullus Simon, 1880 — South America, Guatemala
- Yiinthi Davies, 1994 — 澳大利亚, Papua New Guinea
- Zachria L. Koch, 1875 — 澳大利亚
