头孢洛扎[1](ceftolozane)是第五代头孢类抗生素,用来治疗对常规抗生素耐药的革兰氏阴性菌[2]。实验证明其对尿路感染、腹腔内感染、呼吸机相关性细菌性肺炎有效。
事实速览 臨床資料, 商品名(英语:Drug nomenclature) ...
头孢洛扎 |
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商品名 | Zerbaxa(与他唑巴坦联用时) |
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给药途径 | 静脉注射 |
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法律規範 |
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(6R,7R)-3-([3-Amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl)-7-([(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
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CAS号 | 689293-68-3 Y |
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PubChem CID | |
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CompTox Dashboard (EPA) | |
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化学式 | C23H30N12O8S2 |
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摩尔质量 | 666.69 g·mol−1 |
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3D模型(JSmol) | |
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CC(C)(C(=O)O)O/N=C(/c1nc(sn1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[n+]4cc(c(n4C)N)NC(=O)NCCN)C(=O)[O-]
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InChI=1S/C23H30N12O8S2/c1-23(2,20(40)41)43-31-11(15-30-21(26)45-32-15)16(36)29-12-17(37)35-13(19(38)39)9(8-44-18(12)35)6-34-7-10(14(25)33(34)3)28-22(42)27-5-4-24/h7,12,18,25H,4-6,8,24H2,1-3H3,(H7,26,27,28,29,30,32,36,38,39,40,41,42)/b31-11-/t12-,18-/m1/s1 Key:JHFNIHVVXRKLEF-DCZLAGFPSA-N
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关闭
头孢洛扎常与他唑巴坦与β-内酰胺酶抑制剂他唑巴坦联用,有防止头孢洛扎分解的作用。联用的头孢洛扎/他唑巴坦商品名为“Zerbaxa”[3][4][5][6][7]。证据表明头孢洛扎可以治疗复杂尿路感染与复杂腹腔内感染[8]。
高田田; 沈承武. 新型抗菌药物头孢洛扎/他唑巴坦的研究进展. 解放军药学学报. 2017, 5.
Long, T. E.; Williams, J. T. Cephalosporins currently in early clinical trials for the treatment of bacterial infections. Expert Opinion on Investigational Drugs. 2014, 23 (10): 1375. doi:10.1517/13543784.2014.930127.
Toda, A; Ohki, H; Yamanaka, T; Murano, K; Okuda, S; Kawabata, K; Hatano, K; Matsuda, K; Misumi, K; Itoh, K; Satoh, K; Inoue, S. Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: Discovery of FR264205. Bioorganic & Medicinal Chemistry Letters. 2008, 18 (17): 4849–52. PMID 18701284. doi:10.1016/j.bmcl.2008.07.085.
Zhanel, G. G.; Chung, P; Adam, H; Zelenitsky, S; Denisuik, A; Schweizer, F; Lagacé-Wiens, P. R.; Rubinstein, E; Gin, A. S.; Walkty, A; Hoban, D. J.; Lynch Jp, 3rd; Karlowsky, J. A. Ceftolozane/tazobactam: A novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli. Drugs. 2014, 74 (1): 31–51. PMID 24352909. doi:10.1007/s40265-013-0168-2.