Template:PBB/2064维基媒体模板 / 維基百科,自由的 encyclopedia 事实速览 Erb-b2 receptor tyrosine kinase 2, 有效结构 ...Erb-b2 receptor tyrosine kinase 2 PDB繪製基於1n8z 曲妥珠單抗Fab片段(藍色)結合到HER2(米色)的胞外域。 有效结构 PDB 直系同源检索:PDBe, RCSB PDB查询代码列表 1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3MZW, 3N85, 3PP0, 3RCD 标识代号 ERBB2; CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1扩展标识 遗传学:164870 鼠基因:95410 同源基因:3273 ChEMBL: 1824 GeneCards: ERBB2 GeneEC編號 2.7.10.1 基因本体论描述 分子功能 · RNA polymerase I core binding · protein tyrosine kinase activity · transmembrane receptor protein tyrosine kinase activity · receptor signaling protein tyrosine kinase activity · transmembrane signaling receptor activity · epidermal growth factor-activated receptor activity · protein binding · ATP binding · protein C-terminus binding · growth factor binding · protein phosphatase binding · identical protein binding · ErbB-3 class receptor binding · protein heterodimerization activity · protein dimerization activity 细胞成分 · nucleus · plasma membrane · endosome membrane · integral to membrane · basolateral plasma membrane · apical plasma membrane · receptor complex · perinuclear region of cytoplasm 生物过程 · positive regulation of protein phosphorylation · transcription, DNA-dependent · protein phosphorylation · signal transduction · cell surface receptor signaling pathway · enzyme linked receptor protein signaling pathway · transmembrane receptor protein tyrosine kinase signaling pathway · epidermal growth factor receptor signaling pathway · nervous system development · axon guidance · peripheral nervous system development · heart development · neuromuscular junction development · motor neuron axon guidance · cell proliferation · fibroblast growth factor receptor signaling pathway · phosphatidylinositol 3-kinase cascade · signal transduction by phosphorylation · positive regulation of cell growth · mammary gland development · positive regulation of Rho GTPase activity · regulation of microtubule-based process · negative regulation of immature T cell proliferation in thymus · wound healing · myelination · positive regulation of MAP kinase activity · innate immune response · positive regulation of translation · regulation of angiogenesis · positive regulation of cell adhesion · positive regulation of transcription from RNA polymerase I promoter · positive regulation of transcription from RNA polymerase III promoter · protein autophosphorylation · neurotrophin TRK receptor signaling pathway · phosphatidylinositol-mediated signaling · positive regulation of epithelial cell proliferation · regulation of ERK1 and ERK2 cascade Sources: Amigo / QuickGO RNA表达模式 更多表达数据直系同源体物种 人类 小鼠Entrez 2064 13866Ensembl ENSG00000141736 ENSMUSG00000062312UniProt P04626 P70424mRNA序列 NM_001005862 NM_001003817蛋白序列 NP_001005862 NP_001003817基因位置 Chr 17:37.84 – 37.89 Mb Chr 11:98.41 – 98.44 MbPubMed查询 [1] [2]查论编关闭
事实速览 Erb-b2 receptor tyrosine kinase 2, 有效结构 ...Erb-b2 receptor tyrosine kinase 2 PDB繪製基於1n8z 曲妥珠單抗Fab片段(藍色)結合到HER2(米色)的胞外域。 有效结构 PDB 直系同源检索:PDBe, RCSB PDB查询代码列表 1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3MZW, 3N85, 3PP0, 3RCD 标识代号 ERBB2; CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1扩展标识 遗传学:164870 鼠基因:95410 同源基因:3273 ChEMBL: 1824 GeneCards: ERBB2 GeneEC編號 2.7.10.1 基因本体论描述 分子功能 · RNA polymerase I core binding · protein tyrosine kinase activity · transmembrane receptor protein tyrosine kinase activity · receptor signaling protein tyrosine kinase activity · transmembrane signaling receptor activity · epidermal growth factor-activated receptor activity · protein binding · ATP binding · protein C-terminus binding · growth factor binding · protein phosphatase binding · identical protein binding · ErbB-3 class receptor binding · protein heterodimerization activity · protein dimerization activity 细胞成分 · nucleus · plasma membrane · endosome membrane · integral to membrane · basolateral plasma membrane · apical plasma membrane · receptor complex · perinuclear region of cytoplasm 生物过程 · positive regulation of protein phosphorylation · transcription, DNA-dependent · protein phosphorylation · signal transduction · cell surface receptor signaling pathway · enzyme linked receptor protein signaling pathway · transmembrane receptor protein tyrosine kinase signaling pathway · epidermal growth factor receptor signaling pathway · nervous system development · axon guidance · peripheral nervous system development · heart development · neuromuscular junction development · motor neuron axon guidance · cell proliferation · fibroblast growth factor receptor signaling pathway · phosphatidylinositol 3-kinase cascade · signal transduction by phosphorylation · positive regulation of cell growth · mammary gland development · positive regulation of Rho GTPase activity · regulation of microtubule-based process · negative regulation of immature T cell proliferation in thymus · wound healing · myelination · positive regulation of MAP kinase activity · innate immune response · positive regulation of translation · regulation of angiogenesis · positive regulation of cell adhesion · positive regulation of transcription from RNA polymerase I promoter · positive regulation of transcription from RNA polymerase III promoter · protein autophosphorylation · neurotrophin TRK receptor signaling pathway · phosphatidylinositol-mediated signaling · positive regulation of epithelial cell proliferation · regulation of ERK1 and ERK2 cascade Sources: Amigo / QuickGO RNA表达模式 更多表达数据直系同源体物种 人类 小鼠Entrez 2064 13866Ensembl ENSG00000141736 ENSMUSG00000062312UniProt P04626 P70424mRNA序列 NM_001005862 NM_001003817蛋白序列 NP_001005862 NP_001003817基因位置 Chr 17:37.84 – 37.89 Mb Chr 11:98.41 – 98.44 MbPubMed查询 [1] [2]查论编关闭