SSRI所致的性功能障碍(Post-SSRI sexual dysfunction、縮寫:PSSD)[1]常見症状為:性欲减退、性无能或者阴道润滑度降低、在缺乏欲望的情况下持续性的性唤醒障碍、延迟或者缺乏性高潮、对性刺激的回应缺失或者减弱[2]。初步研究发现,有不到10%患者报告这种症状。实际诊疗中,参与其中的医生陈述,服药的精神方面患者接近60%呈现出这一症状。[3] “自觉报告”这一机制本身被认为是导致其报告数据比针对性询问后得出的数据低的本质原因,抑或者是患者在陈述有关“性功能障碍”方面时存在记忆偏差或羞于启齿。[4]
Zajecka J, Mitchell S, Fawcett J (1997). “Treatment-emergent changes in sexual function with selective serotonin reuptake inhibitors as measured with the Rush Sexual Inventory”. Psychopharmacol Bull 33 (4): 755–60. PMID 9493488 (页面存档备份,存于互联网档案馆)
Montejo AL, Llorca G, Izquierdo JA, et al. (1999). “Sexual dysfunction with antidepressive agents. Effect of the change to amineptine in patients with sexual dysfunction secondary to SSRI“. Actas Esp Psiquiatr (in Spanish; Castilian) 27 (1): 23–34. PMID 10380144 (页面存档备份,存于互联网档案馆).
Safarinejad MR, Hosseini SY (2006). “Safety and efficacy of citalopram in the treatment of premature ejaculation: a double-blind placebo-controlled, fixed dose, randomized study”. Int. J. Impot. Res. 18 (2): 164–9. doi:10.1038/sj.ijir.3901384. PMID 16107866 (页面存档备份,存于互联网档案馆).
Arafa M, Shamloul R (2006). “Efficacy of sertraline hydrochloride in treatment of premature ejaculation: a placebo-controlled study using a validated questionnaire”. Int. J. Impot. Res. 18 (6): 534–8. doi:10.1038/sj.ijir.3901469. PMID 16554853 (页面存档备份,存于互联网档案馆).
Keller Ashton A, Hamer R, Rosen RC (1997). “Serotonin reuptake inhibitor-induced sexual dysfunction and its treatment: a large-scale retrospective study of 596 psychiatric outpatients”. J Sex Marital Ther 23 (3): 165–75. doi:10.1080/00926239708403922. PMID 9292832 (页面存档备份,存于互联网档案馆).
Safarinejad M (September 2010). “The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor: a double-blind placebo-controlled and randomized study”. BJU International.