JWH大麻素列表

克莱门森大学的约翰·威廉·霍夫曼（John William Huffman）研究小组合成了450多种大麻素^[1][2]。其中一些是^[3][4]：

001—100

大麻素及其K_i值^[a]

名称	类别	分子式	Ki/nM (CB1)	Ki/nM (CB2)	选择性	结构	CAS编号
JWH-004	萘甲酰基吲哚	C26H27NO	48 ± 13	4 ± 1.5	CB2 (12x)		155471-11-7
JWH-007[5]	萘甲酰基吲哚	C25H25NO	9.5 ± 4.5	2.9 ± 2.6	CB2 (3.3x)		155471-10-6
JWH-009	萘甲酰基吲哚	C27H29NO	>10000	141 ± 14	CB2 (>70x)		155471-12-8
JWH-011	萘甲酰基吲哚	C27H29NO					155471-13-9
JWH-015[5]	萘甲酰基吲哚	C23H21NO	164 ± 22	13.8 ± 4.6	CB2 (12x)		155471-08-2
JWH-016	萘甲酰基吲哚	C24H23NO	22 ± 1.5	4.3 ± 1.6	CB2 (5.1x)		155471-09-3
JWH-018[5]	萘甲酰基吲哚	C24H23NO	9 ± 5	2.9 ± 2.6	CB2 (3.1x)		209414-07-3
JWH-019	萘甲酰基吲哚	C25H25NO	9.8 ± 2	5.55 ± 2	CB2 (1.77x)		209414-08-4
JWH-020	萘甲酰基吲哚	C26H27NO	128 ± 17	205 ± 20	CB1 (1.6x)		209414-09-5
JWH-030	萘甲酰基吡咯	C20H21NO	87 ± 3	320 ± 127	CB1 (3.7x)		162934-73-8
JWH-031	萘甲酰基吡咯	C21H23NO	399 ± 109				162934-74-9
JWH-032	萘甲酰基吡咯	C18H17NO	>10000	>10000	—		162934-71-6
JWH-033	萘甲酰基吡咯	C19H19NO	666 ± 77				162934-72-7
JWH-036	萘甲酰基吡咯	C22H25NO	309 ± 11				162934-75-0
JWH-042[6]	萘甲酰基吲哚	C21H17NO	>10000	5050 ± 192	CB2		209414-02-8
JWH-043[6]	萘甲酰基吲哚	C22H19NO	1180 ± 44	964 ± 242	CB2 (1.2x)		209414-03-9
JWH-044	萘甲酰基吡咯	C16H13NO	>10000	>10000	—		209414-10-8
JWH-045	萘甲酰基吡咯	C17H15NO	>10000	>10000	—		209414-11-9
JWH-046[6]	萘甲酰基吲哚	C24H23NO	343 ± 38	16.3 ± 4.9	CB2 (21x)		316189-64-7
JWH-047[6]	萘甲酰基吲哚	C25H25NO	59 ± 3	3.47 ± 1.80	CB2 (17x)		316189-65-8
JWH-048[6]	萘甲酰基吲哚	C26H27NO	10.7 ± 1.0	0.49 ± 0.13	CB2 (22x)		316189-66-9
JWH-049[6]	萘甲酰基吲哚	C27H29NO	55.1 ± 17.0	32.3 ± 2.4	CB2 (1.7x)		316189-67-0
JWH-050[6]	萘甲酰基吲哚	C28H31NO	342 ± 6	526 ± 133	CB1 (1.5x)		1348257-03-3
JWH-051	二苯并吡喃	C25H38O2	1.20	0.03	CB2 (40x)		181764-31-8
JWH-056[7]	二苯并吡喃	C21H30O	>10000	32 ± 9	CB2		60856-72-6
JWH-057[8]	二苯并吡喃	C25H38O	23 ± 7	2.9 ± 1.6	CB2 (8x)		105823-04-9
JWH-065[7]	二苯并吡喃	C23H34O	399 ± 76	10 ± 2	CB2 (40x)		259869-56-2
JWH-070[6]	萘甲酰基吲哚	C20H15NO	>10000	>10000			209414-04-0
JWH-071[6]	萘甲酰基吲哚	C21H17NO	1340 ± 123	2940 ± 852	CB1 (2.2x)		209414-05-1
JWH-072	萘甲酰基吲哚	C22H19NO	1050 ± 5.5	170 ± 54	CB2 (6x)		209414-06-2
JWH-073	萘甲酰基吲哚	C23H21NO	8.9 ± 1.8	27 ± 12	CB1 (3x)		208987-48-8
JWH-076[5]	萘甲酰基吲哚	C23H21NO	214 ± 11	106 ± 46	CB2 (2x)		824960-09-0
JWH-077[6]	萘甲酰基吲哚	C21H17NO2	>10000	>10000			210179-35-4
JWH-078[6]	萘甲酰基吲哚	C22H19NO2	817 ± 60	633 ± 116	CB2 (1.3x)		210179-37-6
JWH-079[6]	萘甲酰基吲哚	C23H21NO2	63.0 ± 3.0	32.0 ± 6.0	CB2 (2x)		210179-40-1
JWH-080[6]	萘甲酰基吲哚	C24H23NO2	8.9 ± 1.8	2.21 ± 1.30	CB2 (4x)		210179-44-5
JWH-081[6]	萘甲酰基吲哚	C25H25NO2	1.2 ± 0.03	12.4 ± 2.2	CB1 (10x)		210179-46-7
JWH-082[6]	萘甲酰基吲哚	C26H27NO2	5.3 ± 0.8	6.40 ± 0.94	CB1 (1.2x)		210179-48-9
JWH-083[6]	萘甲酰基吲哚	C27H29NO2	106 ± 12	102 ± 50	—		316189-69-2
JWH-091[9] (Δ8-THCP)	二苯并吡喃	C23H34O2	22.0 ± 3.9				54763-99-4
JWH-093[6]	萘甲酰基吲哚	C27H29NO2	40.7 ± 2.8	59.1 ± 10.5	CB1 (1.45x)		316189-71-6
JWH-094[6]	萘甲酰基吲哚	C24H23NO2	476 ± 67	97.3 ± 2.7	CB2 (4.9x)		316189-70-5
JWH-095[6]	萘甲酰基吲哚	C29H33NO2	140 ± 4.3	312 ± 83	CB1 (2.2x)		316189-73-8
JWH-096[6]	萘甲酰基吲哚	C25H25NO2	33.7 ± 2.9	13.3 ± 5.6	CB2 (2.5x)		316189-72-7
JWH-097[6]	萘甲酰基吲哚	C31H37NO2	455 ± 28	121 ± 15	CB2 (3.8x)		316189-75-0
JWH-098[6]	萘甲酰基吲哚	C26H27NO2	4.5 ± 0.1	1.9 ± 0.3	CB2 (2.4x)		316189-74-9
JWH-099[6]	萘甲酰基吲哚	C27H29NO2	35.3 ± 9.0	17.8 ± 2.9	CB2 (2x)		316189-76-1
JWH-100[6]	萘甲酰基吲哚	C28H31NO2	381 ± 102	155 ± 74	CB2 (2.5x)		316189-77-2

101—200

大麻素及其K_i值

名称	类别	分子式	Ki/nM (CB1)	Ki/nM (CB2)	选择性	结构	CAS编号
JWH-102[7]	二苯并吡喃	C24H38O2	7.9 ± 0.9	5.2 ± 2.0	CB2 (1.5x)		259869-52-8
JWH-103[7]	二苯并吡喃	C24H38O2	28 ± 3	23 ± 7	CB2 (1.2x)		259869-53-9
JWH-116[10]	萘甲酰基吲哚	C26H27NO	52 ± 5				619294-64-3
JWH-120[5]	萘甲酰基吲哚	C23H21NO	1054 ± 31	6.1 ± 0.7	CB2 (173x)		824955-98-8
JWH-121（克羅地亞語：JWH-073 (metilni derivat)）[來源請求]	萘甲酰基吲哚	C24H23NO			—		1354631-21-2
JWH-122[10]	萘甲酰基吲哚	C25H25NO	0.69 ± 0.05	1.2 ± 1.2	—		619294-47-2
JWH-124 (Δ8-Parahexyl)	二苯并吡喃	C22H32O2	41.0 ± 3.8				20622-30-4
JWH-130 (Δ8-THCB)	二苯并吡喃	C20H28O2	65.0 ± 13				51768-59-3
JWH-133[7]	二苯并吡喃	C22H32O	677 ± 132	3.4 ± 1.0	CB2 (200x)		259869-55-1
JWH-138[11]	二苯并吡喃	C24H36O2	8.5 ± 1.4				431041-39-3
JWH-139[12]	二苯并吡喃	C21H30O	2290 ± 505	14 ± 10	CB2 (164x)		259869-54-0
JWH-142[7]	二苯并吡喃	C26H40O2	529 ± 49	35 ± 14	CB2 (15x)		174627-56-6
JWH-143[7]	二苯并吡喃	C26H40O2	924 ± 104	65 ± 8	CB2 (14x)		174627-50-0
JWH-145[13]	萘甲酰基吡咯	C26H25NO	14 ± 2	6.4 ± 0.4	CB2 (2.2x)		914458-19-8
JWH-146[13]	萘甲酰基吡咯	C28H29NO	21 ± 2	62 ± 5	CB2 (3.0x)		914458-21-2
JWH-147[13]	萘甲酰基吡咯	C27H27NO	11 ± 1	7.1 ± 0.2	CB2 (1.5x)		914458-20-1
JWH-148[5]	萘甲酰基吲哚	C24H23NO	123 ± 8	14.0 ± 1.0	CB2 (8x)		824955-99-9
JWH-149[5]	萘甲酰基吲哚	C26H27NO	5.0 ± 2.1	0.73 ± 0.03	CB2 (6.8x)		548461-82-1
JWH-150[13]	萘甲酰基吡咯	C25H23NO	60 ± 1	15 ± 2	CB2 (4x)		914458-18-7
JWH-151[5]	萘甲酰基吲哚	C24H23NO2	>10000	30 ± 1.1	CB2 (>333x)		824961-23-1
JWH-153[5]	萘甲酰基吲哚	C26H27NO2	250 ± 24	11 ± 0.5	CB2 (23x)		824961-58-2
JWH-156[13]	萘甲酰基吡咯	C24H21NO	404 ± 18	104 ± 18	CB2 (4x)		914458-17-6
JWH-159[5]	萘甲酰基吲哚	C26H27NO2	45 ± 1	10.4 ± 1.4	CB2 (4.3x)		824961-62-8
JWH-160[5]	萘甲酰基吲哚	C24H23NO2	1568 ± 201	441 ± 110	CB2 (3.6x)		824961-60-6
JWH-161	二苯并吡喃	C27H33NO2	19.0				1349418-89-8
JWH-163[5]	萘甲酰基吲哚	C23H21NO2	2358 ± 215	138 ± 12	CB2 (17x)		824961-06-0
JWH-164[5]	萘甲酰基吲哚	C25H25NO2	6.6 ± 0.7	6.9 ± 0.2	—		824961-61-7
JWH-165[5]	萘甲酰基吲哚	C23H21NO2	204 ± 26	71 ± 8	CB2 (2.9x)		824961-59-3
JWH-166[5]	萘甲酰基吲哚	C25H25NO2	44 ± 10	1.9 ± 0.08	CB2 (23x)		824961-41-3
JWH-167	苯乙酰吲哚	C21H23NO	90 ± 17	159 ± 14	CB1 (1.77x)		864445-37-4
JWH-171	碳氢	C25H24	51				619294-62-1
JWH-175[10]	萘甲基吲哚	C24H25N	22 ± 2				619294-35-8
JWH-176[10]	碳氢	C25H24	26 ± 4				619294-62-1
JWH-180[5]	萘甲酰基吲哚	C25H25NO	26 ± 2	9.6 ± 2.0	CB2 (2.7x)		824959-87-7
JWH-181[5]	萘甲酰基吲哚	C28H31NO	1.3 ± 0.1	0.62 ± 0.04	CB2 (2.1x)		824960-03-4
JWH-182[5]	萘甲酰基吲哚	C27H29NO	0.65 ± 0.03	1.1 ± 0.1	CB1 (1.7x)		824960-02-3
JWH-184[10]	萘甲基吲哚	C25H27N	23 ± 6				619294-37-0
JWH-185[10]	萘甲基吲哚	C25H27NO	17 ± 3				619294-39-2
JWH-186[14]	二苯并吡喃	C21H30O2	187 ± 23	5.6 ± 1.7	CB2 (33x)		824430-33-3
JWH-187[14]	二苯并吡喃	C22H32O2	84 ± 16	3.4 ± 0.5	CB2 (25x)		824430-34-4
JWH-188[14]	二苯并吡喃	C20H28O2	270 ± 58	18 ± 2	CB2 (15x)		824430-32-2
JWH-189[5]	萘甲酰基吲哚	C26H27NO	52 ± 2	12 ± 0.8	CB2 (4.3x)		824960-01-2
JWH-190[14]	二苯并吡喃	C23H34O2	8.8 ± 1.4	1.6 ± 0.03	CB2 (5.5x)		824430-35-5
JWH-191[14]	二苯并吡喃	C24H36O2	1.8 ± 0.3	0.52 ± 0.03	CB2 (3.5x)		824430-36-6
JWH-192[10]	萘甲基吲哚	C26H28N2O	41 ± 13				619294-55-2
JWH-193[10]	萘甲酰基吲哚	C26H26N2O2	6 ± 1				133438-58-1
JWH-194[10]	萘甲基吲哚	C26H29N	127 ± 19				619294-43-8
JWH-195[10]	萘甲基吲哚	C25H26N2O	113 ± 28				619294-53-0
JWH-196[10]	萘甲基吲哚	C25H27N	151 ± 18				619294-41-6
JWH-197[10]	萘甲基吲哚	C26H29NO	323 ± 98				{619294-45-0
JWH-198[10]	萘甲酰基吲哚	C26H26N2O3	10 ± 2				166599-76-4
JWH-199[10]	萘甲基吲哚	C26H28N2O2	20 ± 2				619294-57-4
JWH-200[10]	萘甲酰基吲哚	C25H24N2O2	42 ± 5				103610-04-4

201—300

大麻素及其K_i值

名称	类别	分子式	Ki/nM (CB1)	Ki/nM (CB2)	选择性	结构	CAS编号
JWH-201[15]	苯乙酰吲哚	C22H25NO2	1064 ± 21	444 ± 14	CB2 (2.4x)		864445-47-6
JWH-202[15]	苯乙酰吲哚	C23H27NO2	1678 ± 63	645 ± 6	CB2 (2.6x)		864445-48-7
JWH-203[15]	苯乙酰吲哚	C21H22ClNO	8.0 ± 0.9	7.0 ± 1.3	—		864445-54-5
JWH-204[15]	苯乙酰吲哚	C22H24ClNO	13 ± 1	25 ± 1	CB1 (1.9x)		864445-55-6
JWH-205[15]	苯乙酰吲哚	C22H25NO	124 ± 23	180 ± 9	CB1 (1.45x)		864445-38-5
JWH-206[15]	苯乙酰吲哚	C21H22ClNO	389 ± 25	498 ± 37	CB1 (1.28x)		864445-58-9
JWH-207[15]	苯乙酰吲哚	C22H24ClNO	1598 ± 134	3723 ± 10	CB1 (2.33x)		864445-59-0
JWH-208[15]	苯乙酰吲哚	C22H25NO	179 ± 7	570 ± 127	CB1 (3.18x)		864445-41-0
JWH-209[15]	苯乙酰吲哚	C23H27NO	746 ± 49	1353 ± 270	CB1 (1.81x)		864445-42-1
JWH-210[5]	萘甲酰基吲哚	C26H27NO	0.46 ± 0.03	0.69 ± 0.01	CB1 (1.5x)		824959-81-1
JWH-211[5]	萘甲酰基吲哚	C25H25NO	70 ± 0.8	12 ± 0.8	CB2 (5.8x)		824959-72-0
JWH-212[5]	萘甲酰基吲哚	C24H23NO	33 ± 0.9	10 ± 1.2	CB2 (3.3x)		824959-71-9
JWH-213[5]	萘甲酰基吲哚	C27H29NO	1.5 ± 0.2	0.42 ± 0.05	CB2 (3.6x)		824959-83-3
JWH-215[14]	二苯并吡喃	C22H32O3	1008 ± 117	85 ± 21	CB2 (12x)		525588-32-3
JWH-216[14]	二苯并吡喃	C21H30O3	1856 ± 148	333 ± 104	CB2 (5.6x)		525588-30-1
JWH-217[14]	二苯并吡喃	C22H32O2	>10000	1404 ± 66	CB2 (>7x)		525588-02-7
JWH-220	碳氢	C26H26	19
JWH-224[14]	二苯并吡喃	C23H34O3	347 ± 34	28 ± 1	CB2 (12.3x)		525588-34-5
JWH-225[14]	二苯并吡喃	C23H34O2	>10000	325 ± 70	CB2 (>31x)		525588-03-8
JWH-226[14]	二苯并吡喃	C24H36O2	4001 ± 282	43 ± 3	CB2 (93x)		525588-04-9
JWH-227[14]	二苯并吡喃	C24H36O3	40 ± 6	4.4 ± 0.3	CB2 (9x)		525588-36-7
JWH-229[16]	二苯并吡喃	C25H38O2	3134 ± 110	18 ± 2	CB2 (174x)		832111-99-6
JWH-230[14]	二苯并吡喃	C25H38O3	15 ± 3	1.4 ± 0.12	CB2 (10.7x)		525588-38-9
JWH-233[14]	二苯并吡喃	C26H40O3	14 ± 3	1.0 ± 0.3	CB2 (14x)		137945-55-2 （(6aR,10aR)） 2309315-66-8 （(6aS,10aS)）
JWH-234[5]	萘甲酰基吲哚	C26H27NO	8.4 ± 1.8	3.8 ± 0.6	CB2 (2.2x)		824960-64-7
JWH-235[5]	萘甲酰基吲哚	C24H23NO	338 ± 34	123 ± 34	CB2 (2.7x)		824960-57-8
JWH-236[5]	萘甲酰基吲哚	C25H25NO	1351 ± 204	240 ± 63	CB2 (5.6x)		824960-63-6
JWH-237[15]	苯乙酰吲哚	C21H22ClNO	38 ± 10	106 ± 2	CB1 (2.8x)		864445-56-7
JWH-239[5]	萘甲酰基吲哚	C26H27NO	342 ± 20	52 ± 6	CB2 (6.6x)		824960-04-5
JWH-240[5]	萘甲酰基吲哚	C28H31NO	14 ± 1	7.2 ± 1.3	CB2 (1.9x)		824960-06-7
JWH-241[5]	萘甲酰基吲哚	C27H29NO	147 ± 20	49 ± 7	CB2 (3.0x)		824960-05-6
JWH-242[5]	萘甲酰基吲哚	C29H33NO	42 ± 9	6.5 ± 0.3	CB2 (6.5x)		824960-07-8
JWH-243[13]	萘甲酰基吡咯	C27H27NO2	285 ± 40	41 ± 3	CB2 (6.95x)		914458-38-1
JWH-244[13]	萘甲酰基吡咯	C27H27NO	130 ± 6	18 ± 1	CB2 (7.22x)		914458-35-8
JWH-245[13]	萘甲酰基吡咯	C26H24ClNO	276 ± 4	25 ± 2	CB2 (11x)		914458-40-5
JWH-246[13]	萘甲酰基吡咯	C26H24ClNO	70 ± 4	16 ± 1	CB2 (4.38x)		914458-32-5
JWH-247[14]	二苯并吡喃	C25H38O2	427 ± 31	99 ± 4	CB2 (4.3x)		873428-67-2
JWH-248[15]	苯乙酰吲哚	C21H22BrNO	1028 ± 39	657 ± 19	CB2 (1.56x)		864445-62-5
JWH-249[15]	苯乙酰吲哚	C21H22BrNO	8.4 ± 1.8	20 ± 2	CB1 (2.38x)		864445-60-3
JWH-250[15]	苯乙酰吲哚	C22H25NO2	11 ± 2	33 ± 2	CB1 (3x)		864445-43-2
JWH-251[15]	苯乙酰吲哚	C22H25NO	29 ± 3	146 ± 36	CB2 (5x)		864445-39-6
JWH-252[15]	苯乙酰吲哚	C23H27NO	23 ± 3	19 ± 1	CB2 (1.2x)		864445-40-9
JWH-253[15]	苯乙酰吲哚	C23H27NO2	62 ± 10	84 ± 12	CB1 (1.35x)		864445-46-5
JWH-254[14]	二苯并吡喃	C23H34O2	4724 ± 509	319 ± 16	CB2 (14.8x)		873428-46-7
JWH-256[14]	二苯并吡喃	C24H36O2	4300 ± 888	97 ± 18	CB2 (44x)		873428-65-0
JWH-258[5]	萘甲酰基吲哚	C26H27NO2	4.6 ± 0.6	10.5 ± 1.3	CB1 (2.3x)		824960-97-6
JWH-259[5]	萘甲酰基吲哚	C24H23NO2	220 ± 29	74 ± 7	CB2 (3.0x)		824960-95-4
JWH-260[5]	萘甲酰基吲哚	C27H29NO2	29 ± 0.4	25 ± 1.9	CB2 (1.2x)		824960-98-7
JWH-261[5]	萘甲酰基吲哚	C25H25NO2	767 ± 105	221 ± 14	CB2 (3.5x)		824960-96-5
JWH-262[5]	萘甲酰基吲哚	C27H29NO	28 ± 3	5.6 ± 0.7	CB2 (5.0x)		824960-71-6
JWH-265[5]	萘甲酰基吲哚	C23H21NO2	3788 ± 323	80 ± 13	CB2 (47x)		824960-73-8
JWH-266[5]	萘甲酰基吲哚	C24H23NO2	>10000	455 ± 55	CB2 (>22x)		824960-74-9
JWH-267[5]	萘甲酰基吲哚	C25H25NO2	381 ± 16	7.2 ± 0.14	CB2 (53x)		824960-76-1
JWH-268[5]	萘甲酰基吲哚	C26H27NO2	1379 ± 193	40 ± 0.6	CB2 (34x)		824960-77-2
JWH-277[14]	二苯并吡喃	C22H34O3	3905 ± 91	589 ± 65	CB2 (6.6x)		883111-60-2
JWH-278[14]	二苯并吡喃	C23H36O3	906 ± 80	69 ± 6	CB2 (13x)		883111-61-3
JWH-292[13]	萘甲酰基吡咯	C27H27NO2	29 ± 1	20 ± 1	CB2 (1.45x)		914458-25-6
JWH-293[13]	萘甲酰基吡咯	C26H24N2O3	100 ± 5	41 ± 4	CB2 (2.44x)		914458-34-7
JWH-298[14]	二苯并吡喃	C22H34O3	812 ± 67	198 ± 23	CB2 (4.1x)		883111-53-3
JWH-299[14]	二苯并吡喃	C23H36O3	415 ± 50	30 ± 2	CB2 (13.8x)		883111-54-4
JWH-300[12]	二苯并吡喃	C22H34O2	118 ± 16	5.3 ± 0.1	CB2 (22x)		883111-58-8

301—400

大麻素及其K_i值

名称	类别	分子式	Ki/nM (CB1)	Ki/nM (CB2)	选择性	结构	CAS编号
JWH-301[14]	二苯并吡喃	C22H34O2	295 ± 64	48 ± 4	CB2 (6.1x)		883111-65-7
JWH-302[15]	苯乙酰吲哚	C22H25NO2	17 ± 2	89 ± 15	CB1 (5.26x)		864445-45-4
JWH-303[15]	苯乙酰吲哚	C22H24ClNO	117 ± 10	138 ± 12	CB1 (1.18x)		864445-57-8
JWH-304[15]	苯乙酰吲哚	C22H24BrNO	3363 ± 332	2679 ± 688	CB2 (1.26x)		864445-63-6
JWH-305[15]	苯乙酰吲哚	C22H24BrNO	15 ± 1.8	29 ± 5	CB1 (1.93x)		864445-61-4
JWH-306[15]	苯乙酰吲哚	C23H27NO2	25 ± 1	82 ± 11	CB1 (3.28x)		864445-44-3
JWH-307[13]	萘甲酰基吡咯	C26H24FNO	7.7 ± 1.8	3.3 ± 0.2	CB2 (2.33x)		914458-26-7
JWH-308[13]	萘甲酰基吡咯	C26H24FNO	41 ± 1	33 ± 2	CB2 (1.24x)		914458-42-7
JWH-309[13]	萘甲酰基吡咯	C30H27NO	41 ± 3	49 ± 7	CB1 (1.20x)		914458-42-7
JWH-310[14]	二苯并吡喃	C21H32O2	1059 ± 51	36 ± 3	CB2 (29x)		883111-57-7
JWH-311[15]	苯乙酰吲哚	C21H22FNO	23 ± 2	39 ± 3	CB1 (1.70x)		864445-49-8
JWH-312[15]	苯乙酰吲哚	C21H22FNO	72 ± 7	91 ± 20	CB1 (1.26x)		864445-50-1
JWH-313[15]	苯乙酰吲哚	C21H22FNO	422 ± 19	365 ± 92	CB2 (1.16x)		864445-52-3
JWH-314[15]	苯乙酰吲哚	C22H24FNO	39 ± 2	76 ± 4	CB1 (1.95x)		864382-14-9
JWH-315[15]	苯乙酰吲哚	C22H24FNO	430 ± 24	182 ± 23	CB2 (3.36x)		864445-51-2
JWH-316[15]	苯乙酰吲哚	C22H24FNO	2862 ± 670	781 ± 105	CB2 (3.66x)		864445-53-4
JWH-336[12]	二苯并吡喃	C21H32O2	4589 ± 367	153 ± 15	CB2 (30x)		883111-64-6
JWH-338[14]	二苯并吡喃	C20H28O	>10000	111 ± 16	CB2 (>90x)		873428-27-4
JWH-339[14]	二苯并吡喃	C21H30O2	>10000	2317 ± 93	CB2 (>4.3x)		873428-28-5
JWH-340[14]	二苯并吡喃	C25H40O3	135 ± 6	30 ± 1	CB2 (4.5x)		259869-53-9
JWH-341[14]	二苯并吡喃	C25H40O3	100 ± 8	10 ± 0.1	CB2 (10x)		259869-52-8
JWH-346[13]	萘甲酰基吡咯	C27H27NO	67 ± 6	39 ± 2	CB2 (1.72x)		914458-29-0
JWH-347[13]	萘甲酰基吡咯	C30H27NO	333 ± 17	169 ± 17	CB2 (1.97x)		914458-43-8
JWH-348[13]	萘甲酰基吡咯	C27H24F3NO	218 ± 19	53 ± 1	CB2 (4.11x)		914458-41-6
JWH-349[14]	二苯并吡喃	C24H38O3	376 ± 1	38 ± 4	CB2 (9.9x)		883111-67-9
JWH-350[12]	二苯并吡喃	C24H38O3	395 ± 50	12 ± 1	CB2 (33x)		883111-59-9
JWH-351[14]	二苯并吡喃	C22H32O2	>10000	295 ± 3	CB2 (>34x)		873428-30-9
JWH-352[14]	二苯并吡喃	C21H30O	>10000	47 ± 2	CB2 (>213x)		873556-64-0
JWH-353[14]	二苯并吡喃	C22H32O	1493 ± 10	31 ± 1	CB2 (48x)		873556-72-0
JWH-354[14]	二苯并吡喃	C23H34O2	1961 ± 21	241 ± 14	CB2 (8.1x)		873428-58-1
JWH-355[14]	二苯并吡喃	C23H34O	2162 ± 220	108 ± 17	CB2 (20x)		873428-49-0
JWH-356[14]	二苯并吡喃	C24H36O2	5837 ± 701	108 ± 17	CB2 (54x)		873428-61-6
JWH-357[14]	二苯并吡喃	C24H36O	647 ± 78	185 ± 4	CB2 (3.5x)		873428-50-3
JWH-358[14]	二苯并吡喃	C25H38O2	1243 ± 266	52 ± 3	CB2 (24x)		873428-63-8
JWH-359	二苯并吡喃	C24H36O2	2918 ± 450	13.0 ± 0.2	CB2 (220x)
JWH-360[14]	二苯并吡喃	C21H30O	2449 ± 606	160 ± 8	CB2 (15x)		873428-44-5
JWH-361[14]	二苯并吡喃	C23H36O2	63 ± 3	2.7 ± 0.1	CB2 (23x)		883111-59-9
JWH-362[14]	二苯并吡喃	C23H36O2	127 ± 8	34 ± 5	CB2 (3.7x)		883111-67-9
JWH-363[13]	萘甲酰基吡咯	C27H24F3NO	245 ± 5	71 ± 1	CB2 (3.45x)		914458-33-6
JWH-364[13]	萘甲酰基吡咯	C28H29NO	34 ± 3	29 ± 1	CB2 (1.17x)		914458-36-9
JWH-365[13]	萘甲酰基吡咯	C28H29NO	17 ± 1	3.4 ± 0.2	CB2 (5.0x)		914458-23-4
JWH-366[13]	萘甲酰基吡咯	C25H24N2O	191 ± 12	24 ± 1	CB2 (7.96x)		914458-44-9
JWH-367[13]	萘甲酰基吡咯	C27H27NO2	53 ± 2	23 ± 1	CB2 (2.30x)		914458-30-3
JWH-368[13]	萘甲酰基吡咯	C26H24FNO2	16 ± 1	9.1 ± 0.7	CB2 (1.76x)		914458-31-4
JWH-369[13]	萘甲酰基吡咯	C26H24ClNO2	7.9 ± 0.4	5.2 ± 0.3	CB2 (1.52x)		914458-27-8
JWH-370[13]	萘甲酰基吡咯	C27H27NO	5.6 ± 0.4	4.0 ± 0.5	CB2 (1.40x)		914458-22-3
JWH-371[13]	萘甲酰基吡咯	C30H33NO	42 ± 1	64 ± 2	CB1 (1.52x)		914458-37-0
JWH-372[13]	萘甲酰基吡咯	C27H24F3NO	77 ± 2	8.2 ± 0.2	CB1 (9.39x)		914458-28-9
JWH-373[13]	萘甲酰基吡咯	C30H33NO	60 ± 3	69 ± 2	CB1 (1.15x)		914458-37-0
JWH-387[17]	萘甲酰基吲哚	C24H22BrNO	1.2 ± 0.1	1.1 ± 0.1	—		1366067-59-5
JWH-398[18]	萘甲酰基吲哚	C24H22ClNO	2.3 ± 0.1	2.8 ± 0.2	CB1 (1.22x)		1292765-18-4

401—

大麻素及其K_i值

名称	类别	分子式	Ki/nM (CB1)	Ki/nM (CB2)	选择性	结构	CAS编号
JWH-416[17]	萘甲酰基吲哚		73 ± 10	3.3 ± 0.1	CB2 (22x)		1366068-19-0
JWH-417[17]	萘甲酰基吲哚		522 ± 58	13 ± 0.2	CB2 (40x)		1366068-23-6
JWH-422[17]	萘甲酰基吲哚		501 ± 48	20 ± 0.4	CB2 (25x)		1366067-69-7
JWH-423[17]	萘甲酰基吲哚		140 ± 10	6.6 ± 0.2	CB2 (21x)		1366067-66-4
JWH-424[17]	萘甲酰基吲哚	C24H22BrNO	21 ± 3.4	5.4 ± 0.2	CB2 (3.9x)		1366068-04-3
JWH-425[17]	萘甲酰基吲哚	C25H24BrNO	54 ± 11	10 ± 0.4	CB2 (5.4x)		1366068-07-6

参见

• AM大麻素列表
• CP大麻素列表
• HU大麻素列表
• 杂项设计师大麻素列表（英语：List of miscellaneous designer cannabinoids）

注释

1. K_i是化合物对大麻素1型受体（CB₁）或大麻素2型受体（CB₂）的结合亲和力

参考资料

1. Manera C, Tuccinardi T, Martinelli A. Indoles and related compounds as cannabinoid ligands. Mini Rev Med Chem. 2008, 8 (4): 370–87. PMID 18473928. doi:10.2174/138955708783955935.
2. Wiley JL, Marusich JA, Huffman JW. Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids. Life Sci. 2014, 97 (1): 55–63. PMC 3944940 . PMID 24071522. doi:10.1016/j.lfs.2013.09.011.
3. Wiley JL, Marusich JA, Thomas BF. Combination Chemistry: Structure-Activity Relationships of Novel Psychoactive Cannabinoids. Curr Top Behav Neurosci. Current Topics in Behavioral Neurosciences. 2017, 32: 231–248. ISBN 978-3-319-52442-9. PMID 27753007. doi:10.1007/7854_2016_17 .
4. Banister SD, Connor M. The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonists as New Psychoactive Substances: Origins. Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 2018, 252: 165–190. ISBN 978-3-030-10560-0. PMID 29980914. doi:10.1007/164_2018_143.
5. Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists. Bioorganic & Medicinal Chemistry. January 2005, 13 (1): 89–112. PMID 15582455. doi:10.1016/j.bmc.2004.09.050.
6. Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding. Drug and Alcohol Dependence. August 2000, 60 (2): 133–40. PMID 10940540. doi:10.1016/S0376-8716(99)00152-0.
7. Huffman JW, Liddle J, Yu S, Aung MM, Abood ME, Wiley JL, Martin BR. 3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorganic & Medicinal Chemistry. December 1999, 7 (12): 2905–14. PMID 10658595. doi:10.1016/s0968-0896(99)00219-9.
8. Huffman JW, Yu S, Showalter V, Abood ME, Wiley JL, Compton DR, Martin BR, Bramblett RD, Reggio PH. Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor. Journal of Medicinal Chemistry. September 1996, 39 (20): 3875–7. PMID 8831752. doi:10.1021/JM960394Y.
9. Bow EW, Rimoldi JM. The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation. Perspect Medicin Chem. 2016 Jun 28;8:17-39. doi:10.4137/PMC.S32171 PMID 27398024
10. Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR. 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor. Bioorganic & Medicinal Chemistry. February 2003, 11 (4): 539–49. PMID 12538019. S2CID 29107765. doi:10.1016/S0968-0896(02)00451-0.
11. Martin BR, Jefferson R, Winckler R, Wiley JL, Huffman JW, Crocker PJ, Saha B, Razdan RK. Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonists. J Pharmacol Exp Ther. 1999 Sep;290(3):1065-79. PMID 10454479
12. Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacological Reviews. June 2002, 54 (2): 161–202. PMID 12037135. S2CID 8259002. doi:10.1124/pr.54.2.161.
13. Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorganic & Medicinal Chemistry Letters. October 2006, 16 (20): 5432–5. PMID 16889960. doi:10.1016/j.bmcl.2006.07.051.
14. Marriott KS, Huffman JW. Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. Current Topics in Medicinal Chemistry. 2008, 8 (3): 187–204. PMID 18289088. doi:10.2174/156802608783498014.
15. Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorganic & Medicinal Chemistry Letters. September 2005, 15 (18): 4110–3. PMID 16005223. doi:10.1016/j.bmcl.2005.06.008.
16. Huffman JW, Bushell SM, Miller JR, Wiley JL, Martin BR. 1-Methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Delta(8)-tetrahydrocannabinols: new selective ligands for the CB2 receptor. Bioorganic & Medicinal Chemistry. December 2002, 10 (12): 4119–29. PMID 12413866. doi:10.1016/s0968-0896(02)00331-0.
17. Wiley JL, Smith VJ, Chen J, Martin BR, Huffman JW. Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents. Bioorganic & Medicinal Chemistry. 2012, 20 (6): 2067–2081. PMC 3298571 . PMID 22341572. doi:10.1016/j.bmc.2012.01.038.
18. The Cannabinoid Receptors. The Receptors. 2009. ISBN 978-1-58829-712-9. doi:10.1007/978-1-59745-503-9.