3-羟基芬纳西泮(英语:3-Hydroxyphenazepam),或叫3-羟基苯那西泮,是一种苯二氮䓬类药物,具有催眠、镇静、抗焦虑和抗惊厥作用。[1]它是芬纳西泮的活性代谢物,[1][2]也是苯二氮䓬类药物前药西那西泮的活性代谢物。[3]相对于芬纳西泮,3-羟基芬纳西泮具有微弱的肌肉松弛特性,但在大多数其他方面大致相当。[1]与其他苯二氮卓类药物一样,3-羟基芬纳西泮可作为GABAA受体苯二氮䓬类位点的正向变构调节剂,EC50值为10.3nM。[4][5][6]它曾作为设计师药物在网上销售。[7][8][9][10]
事实速览 臨床資料, ATC碼 ...
3-羟基芬纳西泮 |
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ATC碼 | |
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法律規範 |
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7-Bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
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CAS号 | 70030-11-4 |
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PubChem CID | |
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ChemSpider | |
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UNII | |
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CompTox Dashboard (EPA) | |
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化学式 | C15H10BrClN2O2 |
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摩尔质量 | 365.61 g·mol−1 |
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3D模型(JSmol) | |
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c1ccc(c(c1)C2=NC(C(=O)Nc3c2cc(cc3)Br)O)Cl
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InChI=1S/C15H10BrClN2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20) Key:KRJKJUWAZOWXNV-UHFFFAOYSA-N
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关闭
Kopanitsa, M. V.; Zbarska, S. M.; Boychuk, Ya. A.; Krishtal, O. A. Modulation of GABA-activated currents by phenazepam and its metabolites in isolated rat purkinje neurons. Neurophysiology. 2000, 32 (3): 192. ISSN 0090-2977. S2CID 32313668. doi:10.1007/BF02506568.
Madeleine Pettersson Bergstrand; Anders Helander; Therese Hansson; Olof Beck. Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays. Drug Testing and Analysis. 2016, 9 (4): 640–645. PMID 27366870. doi:10.1002/dta.2003.
Moosmann, Bjoern; Bisel, Philippe; Franz, Florian; Huppertz, Laura M.; Auwärter, Volker. Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines – an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam, and nitrazolam. Journal of Mass Spectrometry. 2016, 51 (11): 1080–1089. Bibcode:2016JMSp...51.1080M. ISSN 1096-9888. PMID 27535017. doi:10.1002/jms.3840.