王简姬以显贵的豪门世族身份被册立为会稽王司马昱王妃,生世子司马道生。永和四年(348年),王简姬与司马道生不合司马昱的心意,都被幽禁废黜,王简姬于是因为担忧而去世。咸安二年,王简姬的庶子晋孝武帝司马曜即位,于九月甲寅(372年11月6日)追尊王简姬为顺皇后[1][2],与晋简文帝司马昱合葬于高平陵,追尊王简姬父亲王遐为特进、光禄大夫,加散骑常侍[3]。
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