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抑癌蛋白M
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抑癌蛋白M(英語:Oncostatin M,缩写OSM,也译作制癌蛋白M、抑瘤素M)是由人类基因 OSM 编码的蛋白质[5],由209个氨基酸残基组成。OSM是一种多效的细胞因子,属于IL-6家族[6],和白血病抑制因子(LIF)在结构和功能上类似[6],在肝脏发育、造血作用、炎症反应以及中枢神经系统发育和骨形成中有重要作用[7]。
参考文献
- Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Rose TM, Bruce AG. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Natl. Acad. Sci. U.S.A. October 1991, 88 (19): 8641–5. PMC 52565
. PMID 1717982. doi:10.1073/pnas.88.19.8641.
- Tanaka M, Miyajima A. Oncostatin M, a multifunctional cytokine. Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 2003, 149: 39–52. ISBN 978-3-540-20213-4. PMID 12811586. doi:10.1007/s10254-003-0013-1.
- Walker EC, McGregor NE, Poulton IJ, Solano M, Pompolo S, Fernandes TJ, Constable MJ, Nicholson GC, Zhang JG, Nicola NA, Gillespie MT, Martin TJ, Sims NA. Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest. 2010, 120 (2): 582–92 [2019-12-09]. PMC 2810087
. PMID 20051625. doi:10.1172/JCI40568. (原始内容存档于2020-05-29). 简明摘要 – ScienceDaily.
延伸阅读
- Schieven GL, Kallestad JC, Brown TJ, Ledbetter JA, Linsley PS. Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase. J. Immunol. September 1992, 149 (5): 1676–82. PMID 1324279.
- Hermanns HM, Radtke S, Schaper F, Heinrich PC, Behrmann I. Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to the oncostatin M receptor. J. Biol. Chem. December 2000, 275 (52): 40742–8. PMID 11016927. doi:10.1074/jbc.M005408200.
外部链接
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