地特诺(英語:Deterenol ;亦称 Isopropylnorsynephrine、Isopropyloctopamine;商品名Betaphrine)是一种兴奋剂,可作为β肾上腺素受体激动药。其曾被用作膳食补充剂产品的成分,但由于可能导致心脏骤停而在大多数国家被禁用。[1][2][3][4][5]
事实速览 臨床資料, 商品名(英语:Drug nomenclature) ...
地特诺 |
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商品名 | Betaphrine 倍他福林 |
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其他名稱 | Isopropylnorsynephrine, Isopropyloctopamine |
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4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenol
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CAS号 | 7376-66-1 Y |
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PubChem CID | |
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ChemSpider | |
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UNII | |
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KEGG | |
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ChEMBL | |
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CompTox Dashboard (EPA) | |
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化学式 | C11H17NO2 |
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摩尔质量 | 195.26 g·mol−1 |
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3D模型(JSmol) | |
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CC(C)NCC(C1=CC=C(C=C1)O)O
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InChI=1S/C11H17NO2/c1-8(2)12-7-11(14)9-3-5-10(13)6-4-9/h3-6,8,11-14H,7H2,1-2H3 Key:MPCPSVWSWKWJLO-UHFFFAOYSA-N
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关闭
Anderson WG. The sympathomimetic activity of N-isopropyloctopamine in vitro. The Journal of Pharmacology and Experimental Therapeutics. June 1983, 225 (3): 553–8. PMID 6306210.
Mercader J, Wanecq E, Chen J, Carpéné C. Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. Journal of Physiology and Biochemistry. September 2011, 67 (3): 443–52. PMID 21336650. S2CID 22449550. doi:10.1007/s13105-011-0078-2.
Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Testing and Analysis. June 2014, 6 (6): 578–81. PMID 24802503. doi:10.1002/dta.1664.
Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine. Clinical Toxicology. March 2021, 59 (11): 975–981. PMID 33755516. doi:10.1080/15563650.2021.1894333 .