维基百科中的醫學内容
仅供参考,並
不能視作專業意見。如需獲取醫療幫助或意見,请咨询专业人士。詳見
醫學聲明。
吉爾波特症候群(英語:Gilbert's syndrome,簡稱GS)為一種常見的遺傳性肝臟疾病,盛行率約3-12%[1][2][3][4][5]。
患者體内的非共軛性膽紅素會顯著提升,但沒有明顯併發症,患者可能會在運動後產生輕微黃疸。
造成此疾病的原因為患者的葡萄糖醛酸苷轉移酶功能不佳[6][7],使非共軛膽紅素無法轉化為較為水溶的共軛膽紅素。
Dugdale, David C. Gilbert's disease. MedlinePlus. U.S. National Library of Medicine. 2013-05-13 [10 February 2014]. (原始内容存档于2016-07-05).
Bosma, PJ; Chowdhury, JR; Bakker, C; Gantla, S; de Boer, A; Oostra, BA; Lindhout, D; Tytgat, GN; Jansen, PL; Oude Elferink, RP. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome.. The New England Journal of Medicine. 2 November 1995, 333 (18): 1171–5. PMID 7565971. doi:10.1056/nejm199511023331802.
Koiwai, O; Nishizawa, M; Hasada, K; Aono, S; Adachi, Y; Mamiya, N; Sato, H. Gilbert's syndrome is caused by a heterozygous missense mutation in the gene for bilirubin UDP-glucuronosyltransferase.. Human Molecular Genetics. July 1995, 4 (7): 1183–6. PMID 8528206. doi:10.1093/hmg/4.7.1183.
Foulk, WT; Butt, HR; Owen, CA Jr; Whitcomb, FF Jr; Mason, HL. Constitutional hepatic dysfunction (Gilbert's disease): its natural history and related syndromes. Medicine (Baltimore). 1959, 38 (1): 25–46. PMID 13632313.
Wire preaches delights of three cliffs. South Wales Evening Post. 2007-04-27: 3.