unfolded protein response

未折叠蛋白反应（The unfolded protein response, UPR），是一种与内质网（ER）应激相关的细胞应激反应。蛋白质由于各种原因不能正常折叠成二级结构，进而在内质网中累积，从而对细胞产生不利影响。UPR是细胞为移除这些影响而做出的反应。现已发现它在所有哺乳动物物种以及酵母和

Tsuruo, and Akihiro Tomida. Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

arriving at the membrane. It stays associated with the membrane through protein-protein interactions of itself and other membrane associated proteins, such

movement · inflammatory response · immune response · activation of signaling protein activity involved in unfolded protein response · cell cycle arrest ·

P; et al. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Proc. Natl. Acad. Sci. U.S.A. 1995, 92 (19):