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物質濫用（英語：Substance abuse），也稱藥物濫用（Drug abuse），物質使用疾患（substance use disorder, 或是substance misuse disorder），是指使用藥物的數量，或者方法，對於本身，或者對於他人發生危害的情況。這是一種物質相關疾患（英语：substance-related
The diverse therapeutic actions of pregabalin: is a single mechanism responsible for several pharmacological activities?. Trends in Pharmacological Sciences
use in the United States?. National Institute on Drug Abuse. [2018-12-10]. （原始内容存档于2018-12-10） （英语）. Valencia, Marie. Record 29 million people drug-dependent
物質依賴
to repeated drug administration, and is unmasked during withdrawal, which occurs when drug taking stops. Dependence from long-term drug use may have both
new era – the use of ΔFosB as a biomarker. If ΔFosB detection is indicative of chronic drug exposure (and is at least partly responsible for dependence