EGR3

早期生長反應蛋白3（英語：Early growth response protein 3，EGR-3）是一個由人類基因EGR3編碼的蛋白質^[1][2][3]。

早期生長應答蛋白3 Early growth response 3
標識
代號	EGR3; EGR-3; PILOT
擴展標識	遺傳學：602419 鼠基因：1306780 同源基因：37923 GeneCards: EGR3 Gene
基因本體論描述 分子功能 · DNA binding · sequence-specific DNA binding transcription factor activity · zinc ion binding 細胞成分 · nucleus 生物過程 · positive regulation of endothelial cell proliferation · cell migration involved in sprouting angiogenesis · transcription, DNA-dependent · neuromuscular synaptic transmission · peripheral nervous system development · muscle organ development · circadian rhythm · endothelial cell chemotaxis · cellular response to vascular endothelial growth factor stimulus · negative regulation of apoptotic process · cellular response to fibroblast growth factor stimulus Sources: Amigo / QuickGO
RNA表達模式
更多表達數據
直系同源體
物種	人類	小鼠
Entrez	1960	13655
Ensembl	ENSG00000179388	ENSMUSG00000033730
UniProt	Q06889	P43300
mRNA序列	NM_001199880	NM_018781
蛋白序列	NP_001186809	NP_061251
基因位置	Chr 8: 22.55 – 22.55 Mb	Chr 14: 70.08 – 70.08 Mb
PubMed查詢	[1]	[2]
閱 論 編

該基因編碼的蛋白為EGR家族的Cys2His2型鋅指結構轉錄因子。這是一個是由有絲分裂刺激誘導的早期生長反應基因。由該基因編碼的蛋白參與了控制生物節律的轉錄調控。它也可能在肌肉發育中起作用。^[3]

參考文獻

1. Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP. EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene. Aug 1991, 6 (6): 917–28. PMID 1906159.
2. Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD. HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter. J Biol Chem. May 2002, 277 (22): 19482–19487. PMID 11909874. doi:10.1074/jbc.M201687200.
3. Entrez Gene: EGR3 early growth response 3. （原始內容存檔於2019-10-16）.

延伸閱讀

• Yamada K; Gerber DJ; Iwayama Y; et al. Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (8): 2815–2820. PMC 1815264 . PMID 17360599. doi:10.1073/pnas.0610765104.
• Gerhard DS; Wagner L; Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–2127. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
• Yoo YG, Lee MO. Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor. J. Biol. Chem. 2004, 279 (35): 36242–36249. PMID 15173177. doi:10.1074/jbc.M401290200.
• Inoue A; Omoto Y; Yamaguchi Y; et al. Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells. J. Mol. Endocrinol. 2005, 32 (3): 649–661. PMID 15171706. doi:10.1677/jme.0.0320649.
• Liu D; Jia H; Holmes DI; et al. Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. Arterioscler. Thromb. Vasc. Biol. 2004, 23 (11): 2002–2007. PMID 14525795. doi:10.1161/01.ATV.0000098644.03153.6F.
• Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–16903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
• Tourtellotte WG, Milbrandt J. Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat. Genet. 1998, 20 (1): 87–91. PMID 9731539. doi:10.1038/1757.
• Morris ME; Viswanathan N; Kuhlman S; et al. A screen for genes induced in the suprachiasmatic nucleus by light. Science. 1998, 279 (5356): 1544–1547. PMID 9488654. doi:10.1126/science.279.5356.1544.
• Hillier LD; Lennon G; Becker M; et al. Generation and analysis of 280,000 human expressed sequence tags. Genome Res. 1997, 6 (9): 807–828. PMID 8889549. doi:10.1101/gr.6.9.807.
• Mages HW; Stamminger T; Rilke O; et al. Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells. Int. Immunol. 1993, 5 (1): 63–70. PMID 8443122. doi:10.1093/intimm/5.1.63.

外部連結

• 醫學主題詞表（MeSH）：EGR3+protein,+human

EGR3引用了美國國家醫學圖書館提供的資料，這些資料屬於公共領域。