G-四聯體(英語:G-quadruplexG-tetradsG4-DNA)是一種由富含鳥嘌呤的核酸序列所構成的四股型態。含有經由胡斯坦(Hoogsteen)氫鍵維持穩定,並由鳥嘌呤以正方形方式排列而成的結構。在方形中央有一個單價陽離子(通常是[1]。這種結構可見於DNARNALNA(鎖核酸)與PNA(肽核酸);根據形成四聯體的各股的方向,可能有分子內(intramolecular)、雙分子(bimolecular)或四分子(tetramolecular)等不同類型[2]

在四聯體的結構中,我們可以根據四股的方向,將結構分為平行反平行英語Antiparallel (biochemistry)

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Structure of a G-quadruplex. Left: a G-tetrad. Right: an intramolecular G-quadruplex
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3D Structure of the intramolecular human telomeric G-quadruplex in potassium solution (PDB ID 2HY9). The backbone is represented by a tube. The center of this structure contains three layers of G-tetrads. The hydrogen bonds in these layers are represented by blue dashed lines.

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