14號染色體是人類23對染色體中的一對,正常人擁有2條14號染色體。14號染色體纏繞了約1億700萬鹼基對(構築DNA的材料),並包含了人類細胞中約3%至3.5%的DNA。每條染色體上的基因識別是遺傳研究活躍的領域。因為研究人員使用不同的方法來進行對於每一條染色體基因數目的預測,而基因數目的估計會有所變化。14號染色體的基因數目有可能介於700個至1300個。
Quick Facts 14號染色體, 特徵 ...
Close
Quick Facts 14號染色體 ...
14號染色體
|
|
物種
|
Homo sapiens
|
基因數量
|
1,655
|
Close
14號染色體基因組成有ATXN3、COCH、GALC、GCH1、IGH@、IFT43、MYH7[2]、NPC2、PSEN1、SERPINA1、TSHR以及FAM71D,詳細基因組成的介紹請參見英文版本的維基百科。
下列與14號人類染色體的基因異常有關的疾病或症狀:
- Campo E. Genetic and molecular genetic studies in the diagnosis of B-cell lymphomas I: mantle cell lymphoma, follicular lymphoma, and Burkitt's lymphoma. Hum Pathol. 2003, 34 (4): 330–5. PMID 12733111. doi:10.1053/hupa.2003.97.(英文)
- Gilbert F. Disease genes and chromosomes: disease maps of the human genome. Chromosome 14. Genet Test. 1999, 3 (4): 379–91. PMID 10627948.(英文)
- Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Jean Weissenbach. The DNA sequence and analysis of human chromosome 14. Nature. 2003, 421 (6923): 601–7. PMID 12508121. doi:10.1038/nature01348.(英文)
- Kamnasaran D, Cox DW. Current status of human chromosome 14. J Med Genet. 2002, 39 (2): 81–90. PMC 1735028 . PMID 11836355. doi:10.1136/jmg.39.2.81.(英文)
- Lemire EG, Cardwell S. Unusual phenotype in partial trisomy 14. Am J Med Genet. 1999, 87 (4): 294–6. PMID 10588832. doi:10.1002/(SICI)1096-8628(19991203)87:4<294::AID-AJMG2>3.0.CO;2-S.(英文)
- van Karnebeek CD, Quik S, Sluijter S, Hulsbeek MM, Hoovers JM, Hennekam RC. Further delineation of the chromosome 14q terminal deletion syndrome. Am J Med Genet. 2002, 110 (1): 65–72. PMID 12116274. doi:10.1002/ajmg.10207.(英文)