1,3,4-噁二唑是一種含氮和氧的雜環化合物,是噁二唑的四種異構體之一。[1][2]
Quick Facts 1,3,4-噁二唑, 識別 ...
Close
1,3,4-噁二唑本身在有機化學中並不常用,但它的許多衍生物很重要。例如,拉替拉韋是一種含有1,3,4-噁二唑環的HIV藥物。其他含有1,3,4-噁二唑環的藥物包括酚二唑、齊泊騰坦和硫達唑嗪。
1,3,4-噁二唑衍生物可以通過多種方式合成。[3]一種途徑是在醛存在下氧化四唑。[4]類似地,四唑與醯氯反應生成噁二唑。[5]這兩種方法都涉及N2的釋放。
Bala, Suman; Kamboj, Sunil; Kajal, Anu; Saini, Vipin; Prasad, Deo Nanadan. 1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies. BioMed Research International. 2014, 2014: 172791. PMC 4131560 . PMID 25147788. doi:10.1155/2014/172791 .
Wang, Liang; Cao, Jing; Chen, Qun; He, Mingyang. One-Pot Synthesis of 2,5-Diaryl 1,3,4-Oxadiazoles via Di-tert-butyl Peroxide Promoted Acylation of Aryl Tetrazoles with Aldehydes. The Journal of Organic Chemistry. 2015-04-17, 80 (9): 4743–4748. PMID 25860162. doi:10.1021/acs.joc.5b00207.
Wong, Michael Y.; Krotkus, Simonas; Copley, Graeme; Li, Wenbo; Murawski, Caroline; Hall, David; Hedley, Gordon J.; Jaricot, Marie; Cordes, David B.; Slawin, Alexandra M. Z.; Olivier, Yoann; Beljonne, David; Muccioli, Luca; Moral, Monica; Sancho-Garcia, Juan-Carlos; Gather, Malte C.; Samuel, Ifor D. W.; Zysman-Colman, Eli. Deep-Blue Oxadiazole-Containing Thermally Activated Delayed Fluorescence Emitters for Organic Light-Emitting Diodes. ACS Applied Materials & Interfaces. 2018-09-07, 10 (39): 33360–33372. PMID 30192504. doi:10.1021/acsami.8b11136. hdl:10023/18433 .