顆粒溶素(英語:Granulysin,又譯為「顆粒溶解素」)是一種由細胞毒性T細胞(CD8陽性T細胞)在接觸被感染的細胞時釋放的物質。其功能為通過靶細胞的膜上形成的小孔,從而誘導靶細胞凋亡,另外也與抗微生物相關[1]。
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顆粒溶素是一種能產生細胞溶解和發炎反應的分子,最早通過抑制消減雜交尋找在人細胞毒性T細胞活化3–5天時表現的基因發現。顆粒溶素會與具有穿孔能力的穿孔素和顆粒酶形成溶細胞顆粒。顆粒溶素具有廣譜的抗微生物功能,能殺傷結核桿菌、瘧原蟲等,甚至能殺傷一些腫瘤。一系列源自顆粒溶素的胺基酸序列的多肽能作為潛在的抗細菌藥。
顆粒溶素最近被認為與史蒂芬斯-強森症候群的發生發展有關。
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- da Silva AP, Unks D, Lyu SC, et al. In vitro and in vivo antimicrobial activity of granulysin-derived peptides against Vibrio cholerae. J. Antimicrob. Chemother. May 2008, 61 (5): 1103–9. PMC 2664651
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- Chung WH, Hung SI, Yang JY, Su SC, Huang SP, Wei CY, Chin SW, Chiou CC, Chu SC, Ho HC, Yang CH, Lu CF, Wu JY, Liao YD, Chen YT. Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med. Dec 2008, 14 (12): 1343–50. doi:10.1038/nm.1884.