視黃酸受體α(英語:Retinoic acid receptor alpha,RAR-α),也稱為NR1B1(核受體第一亞族B組成員1,nuclear receptor subfamily 1, group B, member 1)是一個核受體,在人類基因組中由 RARA 基因編碼。[6][7]
Quick Facts 視黃酸受體α, 已知的結構 ...
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視黃酸受體α可以與下列蛋白質發生進行交互作用:
- BAG1,[8]
- CLOCK,[9]
- CCND3,[10]
- NCOA6,[11][12][13]
- NCOR1,[14][15]
- NCOR2,[16][17]
- NPAS2,[9]
- NRIP1,[18][19][20]
- NR0B2,[21][22]
- NR4A2,[23]
- PML[24]
- RXRA.[25][26]
- Src,[27][28]
- TADA3L,[29]
- ZBTB16.[30]
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Dong S, Tweardy DJ. Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. Blood. April 2002, 99 (8): 2637–46. PMID 11929748. doi:10.1182/blood.V99.8.2637.
Hu X, Chen Y, Farooqui M, Thomas MC, Chiang CM, Wei LN. Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation. J. Biol. Chem. January 2004, 279 (1): 319–25. PMID 14581481. doi:10.1074/jbc.M307621200.
Farooqui M, Franco PJ, Thompson J, Kagechika H, Chandraratna RA, Banaszak L, Wei LN. Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity. Biochemistry. February 2003, 42 (4): 971–9. PMID 12549917. doi:10.1021/bi020497k.
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Perlmann T, Jansson L. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. April 1995, 9 (7): 769–82. PMID 7705655. doi:10.1101/gad.9.7.769.
Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat. Genet. November 1999, 23 (3): 287–95. PMID 10610177. doi:10.1038/15463.
Zeng M, Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H, Band V. Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator. J. Biol. Chem. November 2002, 277 (47): 45611–8. PMID 12235159. doi:10.1074/jbc.M208447200.
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