胰島素樣生長因子1(英語:Insulin-like growth factor 1,IGF-1)也被稱為生長調節素C(somatomedin C),是一個由人類基因 IGF1 編碼的蛋白質[6][7]。在1970年代,IGF-1也曾經被稱為「酸硫化因子」[8],並認為其作用為「不受抑制的胰島樣活力」(nonsuppressible insulin-like activity,NSILA)。
Quick Facts 胰島素樣生長因子1, 已知的結構 ...
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IGF-1是一個在三級結構上與胰島素類似的激素,在兒童成長發育中有重要作用,並持續在成人的合成代謝中起作用。一種人工合成的IGF-1類似物,美卡舍明,用於治療發育停滯[9]。
IGF-1蛋白由一個肽鏈構成,包括70個胺基酸殘基和三個分子內二硫鍵,分子量為7,649道爾頓[10]。
已經發現,腦垂腺前部的生長激素(GH)分泌受到GH釋放激素( GHRH )和體抑素的調節,GHRH和體抑素之間的相互作用引起搏動性GH分泌,在青春期最高。GH誘導肝臟中胰島素樣生長因子1的產生,並調節許多其他組織中IGF-1的旁分泌。IGF-1是GH的合成代謝和促有絲分裂活性的介體。
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