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吉田真由美因為喜歡水野英子和西谷祥子的作品，小學時起練習畫漫畫。高中開始投稿雜誌《瑪格麗特》、《Ribon》，1973年以〈朋の願いはいつ…〉得獎出道[1] 。
吉田真由美和漫畫家赤星民子（赤星たみこ）是多年好友。[3]
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