KLF4

Kruppel样因子4（英语：Kruppel-like factor 4，缩写KLF4）或肠富集Krüppel样因子（英语：gut-enriched Krüppel-like factor，缩写GKLF）是锌指转录因子KLF家族的一个成员，后者属于一个较大的SP1（英语：Sp1 transcription factor）样转录因子家族^[5][6][7]。KLF4参与细胞增殖、细胞分化、细胞凋亡和体细胞重编程（英语：Reprogramming）的调节。有证据表明KLF4在包括大肠癌在内的一些癌症中是肿瘤抑制基因^[8]。与KLF2（英语：KLF2）类似，它在C端有三个C2H2型锌指^[6]。它有两个核定位序列指引它定位于细胞核内^[9]。在胚胎干细胞(ESCs)和间充质干细胞(MSCs)中KLF4是显示多能化的很好标记。

KLF4
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 2WBS、​2WBU、​4M9E
识别号
别名	KLF4；, EZF, GKLF, Kruppel-like factor 4 (gut), Kruppel like factor 4
外部ID	OMIM：602253 MGI：1342287 HomoloGene：3123 GeneCards：KLF4
基因位置（人类） 染色体 9号染色体[1] 基因座 9q31.2 起始 107,484,852 bp[1] 终止 107,490,482 bp[1]
基因位置（小鼠） 染色体 小鼠4号染色体[2] 基因座 4 B3|4 29.76 cM 起始 55,527,143 bp[2] 终止 55,532,466 bp[2]
RNA表达模式
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基因本体 分子功能 • DNA结合 • sequence-specific DNA binding • beta-catenin binding • phosphatidylinositol 3-kinase regulator activity • DNA结合转录因子活性 • 锌离子结合 • DNA-binding transcription activator activity, RNA polymerase II-specific • 转录因子结合 • 核心启动子近端区域序列特异性DNA结合 • 金属离子结合 • RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity • 血浆蛋白结合 • nucleic acid binding • double-stranded DNA binding • promoter-specific chromatin binding • RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific • transcription coregulator binding • histone deacetylase binding 细胞组分 • 细胞质 • 转录调节复合物 • 核质 • 染色质 • 细胞核 生物学过程 • negative regulation of chemokine (C-X-C motif) ligand 2 production • epidermal cell differentiation • cellular response to retinoic acid • negative regulation of protein kinase B signaling • negative regulation of muscle hyperplasia • 平滑肌细胞增殖的负调控 • positive regulation of protein metabolic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of axon regeneration • cellular response to peptide • regulation of transcription, DNA-templated • positive regulation of hemoglobin biosynthetic process • response to retinoic acid • somatic stem cell population maintenance • cellular response to laminar fluid shear stress • regulation of transcription by RNA polymerase II • 细胞分化 • epidermis morphogenesis • positive regulation of nitric oxide biosynthetic process • cellular response to growth factor stimulus • cellular response to organic cyclic compound • post-embryonic hemopoiesis • negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • response to organic substance • negative regulation of gene expression • negative regulation of response to cytokine stimulus • transcription, DNA-templated • negative regulation of DNA-binding transcription factor activity • negative regulation of phosphatidylinositol 3-kinase signaling • stem cell population maintenance • negative regulation of cell migration involved in sprouting angiogenesis • positive regulation of gene expression • negative regulation of cell migration • regulation of cell population proliferation • post-embryonic camera-type eye development • regulation of phosphatidylinositol 3-kinase activity • positive regulation of telomerase activity • canonical Wnt signaling pathway • negative regulation of ERK1 and ERK2 cascade • regulation of cell differentiation • mesodermal cell fate determination • negative regulation of heterotypic cell-cell adhesion • negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • cellular response to cycloheximide • negative regulation of inflammatory response • fat cell differentiation • positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • cellular response to hydrogen peroxide • negative regulation of leukocyte adhesion to arterial endothelial cell • positive regulation of core promoter binding • cellular response to leukemia inhibitory factor • negative regulation of angiogenesis • pri-miRNA transcription by RNA polymerase II • negative regulation of G1/S transition of mitotic cell cycle • positive regulation of transcription, DNA-templated • positive regulation of sprouting angiogenesis Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	9314	16600
Ensembl	ENSG00000136826	ENSMUSG00000003032
UniProt	O43474	Q60793
mRNA​序列	NM_001314052 ​NM_004235	NM_010637
蛋白序列	NP_001300981 ​NP_004226	NP_034767
基因位置​（UCSC）	Chr 9: 107.48 – 107.49 Mb	Chr 4: 55.53 – 55.53 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

参考

1. GRCh38: Ensembl release 89: ENSG00000136826 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003032 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Black AR, Black JD, Azizkhan-Clifford J. Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. Journal of Cellular Physiology. August 2001, 188 (2): 143–60. PMID 11424081. doi:10.1002/jcp.1111.
6. Dang DT, Pevsner J, Yang VW. The biology of the mammalian Krüppel-like family of transcription factors. The International Journal of Biochemistry & Cell Biology. November 2000, 32 (11–12): 1103–21. PMC 2754176 . PMID 11137451. doi:10.1016/s1357-2725(00)00059-5.
7. Kaczynski J, Cook T, Urrutia R. Sp1- and Krüppel-like transcription factors. Genome Biology. 2003, 4 (2): 206. PMC 151296 . PMID 12620113. doi:10.1186/gb-2003-4-2-206.
8. El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW. Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Molecular Cancer. August 2013, 12: 89. PMC 3750599 . PMID 23919723. doi:10.1186/1476-4598-12-89.
9. Shields JM, Yang VW. Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins. The Journal of Biological Chemistry. July 1997, 272 (29): 18504–7. PMC 2268085 . PMID 9218496. doi:10.1074/jbc.272.29.18504.

外部链接

• 医学主题词表（MeSH）：KLF4+protein,+human
• KLF4 microarray expression results and literature^{[失效链接]}

KLF4引用了美国国家医学图书馆提供的数据，这些数据属于公共领域。