Cytolysis

穿孔素（英語：Perforin）是人體內一類由PRF1基因编码的蛋白質。 穿孔素是一種由细胞毒性T细胞或自然殺傷細胞分泌的細胞溶解（英语：Cytolysis）蛋白質。它們會插入靶細胞的細胞膜中，並形成孔隙。穿孔素的MACPF（英语：MACPF）域能夠促使細胞溶解。該域與革蘭氏陽性菌的膽固醇依賴性溶細胞素有一定的同源型。

Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci U S A. 1982, 79 (23): 7489–93

proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis. Nature. 1986, 322 (6082): 831–4. PMID 2427956. doi:10.1038/322831a0. 

in microbiology 7.9 (1999): 356-361. Mayer, Manfred M. "Mechanism of cytolysis by complement." Proceedings of the National Academy of Sciences 69.10

extracellular space 生物过程 · inflammatory response · cell wall macromolecule catabolic process · cytolysis · defense response to bacterium Sources: Amigo / QuickGO