278号美国国道(英语:U.S. Route 278)是78号美国国道的一条辅助线,长1728公里,东起南卡罗来纳州希尔顿黑德岛,西至阿肯色州威克斯与71号美国国道交汇。这条公路穿过该城市和城镇有佐治亚州的奥古斯塔、亚特兰大、阿拉巴马州的加兹登和卡尔曼,以及密西西比州的图珀洛、牛津,和格林威尔和阿肯色州的霍普。
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