顺乌头酸酶[3](英语:aconitase,简称为乌头酸酶,EC 4.2.1.3)是一种在三羧酸循环中催化柠檬酸通过顺乌头酸中间步骤立体专一性可逆异构化为异柠檬酸的酶,这是一个非氧化还原步骤[4][5][6]。
Quick Facts 乌头酸水合酶, 命名 ...
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Quick Facts 顺乌头酸酶家族 (乌头酸水合酶), 鉴定 ...
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从细菌到人类,顺乌头酸酶都可以被表达出来。人类表达以下两种同工酶:
More information 顺乌头酸酶1,可溶性, 识别 ...
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PDB 7ACN; Lauble, H.; Kennedy, M. C.; Beinert, H.; Stout, C. D. Crystal structures of aconitase with isocitrate and nitroisocitrate bound. Biochemistry. 1992, 31 (10): 2735–48. PMID 1547214. doi:10.1021/bi00125a014.
PDB 1ACO; Lauble, H; Kennedy, MC; Beinert, H; Stout, CD. Crystal Structures of Aconitase with Trans-aconitate and Nitrocitrate Bound. Journal of Molecular Biology. 1994, 237 (4): 437–51. PMID 8151704. doi:10.1006/jmbi.1994.1246.
Flint, Dennis H.; Allen, Ronda M. Iron−Sulfur Proteins with Nonredox Functions. Chemical Reviews. 1996, 96 (7): 2315–34. doi:10.1021/cr950041r.
Beinert, Helmut; Kennedy, Mary Claire; Stout, C. David. Aconitase as Iron−Sulfur Protein, Enzyme, and Iron-Regulatory Protein. Chemical Reviews. 1996, 96 (7): 2335–74. doi:10.1021/cr950040z.
- Frishman, Dmitrij; Hentze, Matthias W. Conservation of Aconitase Residues Revealed by Multiple Sequence Analysis. Implications for Structure/Function Relationships. European Journal of Biochemistry. 1996, 239 (1): 197–200. PMID 8706708. doi:10.1111/j.1432-1033.1996.0197u.x.