细胞病变作用(英语:Cytopathic effect,简称:CPE)是细胞出现异常的生长或突变,通常和病毒感染有关。在病毒培养的组织琼脂上,病毒的扩散受到了紧密琼脂(Agarose)的限制。所以病毒只能感染旁边的细胞。被病毒感染后的细胞通常会在病毒分离后死亡所以在琼脂上留下透明的圈。

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