王瑾北直隶束鹿人,明朝军事将领,靖远伯王骥之孙。

嘉靖初年,担任三千营提督,协守南京应天府,之后掌管左军都督府。随后,佩征蛮将军印,镇守两广,平定新宁新兴思平等地瑶族叛变。嘉靖三十五年(1556年),与巡抚都御史谈恺檄诸路土兵诛其魁陈以明,后加封太子太保。随后,其督军分道进剿扶藜葵梅等地诸山峒冯天恩叛乱,随后因功荫一子锦衣卫百户。后因言官弹劾他做事横暴,召还[1]

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