奥昔非君

奥昔非君
临床资料
AHFS/Drugs.com	国际药品名称
ATC码	C01DX03 (WHO) ;
识别信息
	IUPAC命名法 (RS)-3-[(2-Hydroxy-1-methyl-2-phenylethyl)amino]-1-(3-methoxyphenyl)propan-1-one; ;
CAS号	15687-41-9
PubChem CID	27454; 5489013;
ChemSpider	4590049;
UNII	DWL616XF1K;
KEGG	D08321 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID0023408 ;
化学信息
化学式	C19H23NO3
摩尔质量	313.40 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C[C@@H]([C@@H](c1ccccc1)O)NCCC(=O)c2cccc(c2)OC;
	InChI InChI=1S/C19H23NO3/c1-14(19(22)15-7-4-3-5-8-15)20-12-11-18(21)16-9-6-10-17(13-16)23-2/h3-10,13-14,19-20,22H,11-12H2,1-2H3/t14-,19-/m0/s1; Key:GDYUVHBMFVMBAF-LIRRHRJNSA-N;

奥昔非君（INN：oxyfedrine）是一种血管扩张剂^[1]和β肾上腺素受体激动剂。^[2]^[3]

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研究发现，它可以抑制冠状血管的张力，^[4]改善心肌代谢（使心脏更好地撑过缺氧），并发挥正变时（英语：Chronotropic）和正性肌力（英语：Inotrope）作用，从而避免诱发心绞痛。^[4]^[5]正性变时性和正性肌力作用尤其重要，因为用于心绞痛的其他血管扩张剂可能会适得其反，导致冠状动脉窃血（英语：Coronary steal）现象。^[6]

有研究提出奥昔非君可与抗生素产生协同作用。^[7]

合成

专利：^[8]

参考资料

[1]
Otsuki, Yuji; Yamasaki, Juntaro; Suina, Kentaro; Okazaki, Shogo; Koike, Naoyoshi; Saya, Hideyuki; Nagano, Osamu. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy. Cancer Science. 2020-01, 111 (1) [2024-05-09]. ISSN 1349-7006. PMC 6942438 . PMID 31692172. doi:10.1111/cas.14224. （原始内容存档于2024-05-09）.
[2]
Sakai, Kazushige; Shiraki, Yasuyuki; Hashimoto, Koroku. An analysis of the ß-adrenergic action of oxyfedrine. European Journal of Pharmacology. 1973-01-01, 21 (1). ISSN 0014-2999. doi:10.1016/0014-2999(73)90210-0.
[3]
Beckett, P. R.; Foster, R. W. Oxyfedrine — A partial agonist at β-adrenoceptors. European Journal of Pharmacology. 1972-11-01, 20 (2). ISSN 0014-2999. doi:10.1016/0014-2999(72)90145-8.
[4]
Chichkanov, G. G.; Chumburidze, V. B. [Mechanism of the antianginal action of oxyfedrine]. Farmakologiia I Toksikologiia. 1977, 40 (3) [2024-05-09]. ISSN 0014-8318. PMID 20326. （原始内容存档于2024-06-14）.
[5]
Jc, Kaski; L, Araujo; A, Maseri. Effects of oxyfedrine on regional myocardial blood flow in patients with coronary artery disease. Cardiovascular drugs and therapy. 1991 Dec, 5 (6) [2024-05-09]. ISSN 0920-3206. PMID 1801897. doi:10.1007/BF00143526. （原始内容存档于2024-05-09）（英语）. 请检查|date=中的日期值 (帮助)
[6]
Chichkanov, G. G.; Bogolepov, A. K.; Matsievskiĭ, D. D. [Mechanism of the effect of anti-angina drugs with adrenergic beta receptor agonist action on the collateral hemodynamics and redistribution of the blood flow in chronic myocardial ischemia]. Kardiologiia. 1981-10, 21 (10). ISSN 0022-9040. PMID 6117671.
[7]
Mazumdar K, Dutta NK, Kumar KA, Dastidar SG. In vitro and in vivo synergism between tetracycline and the cardiovascular agent oxyfedrine HCl against common bacterial strains. Biological & Pharmaceutical Bulletin. April 2005, 28 (4): 713–7 [2024-05-09]. PMID 15802815. doi:10.1248/bpb.28.713 . （原始内容存档于2024-06-06）.
[8]
Thiele Kurt, 美国专利第3,225,095号 (1965 to Degussa).

[pmid31692172-1] [1]
Otsuki, Yuji; Yamasaki, Juntaro; Suina, Kentaro; Okazaki, Shogo; Koike, Naoyoshi; Saya, Hideyuki; Nagano, Osamu. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy. Cancer Science. 2020-01, 111 (1) [2024-05-09]. ISSN 1349-7006. PMC 6942438 . PMID 31692172. doi:10.1111/cas.14224. （原始内容存档于2024-05-09）.

[2] [2]
Sakai, Kazushige; Shiraki, Yasuyuki; Hashimoto, Koroku. An analysis of the ß-adrenergic action of oxyfedrine. European Journal of Pharmacology. 1973-01-01, 21 (1). ISSN 0014-2999. doi:10.1016/0014-2999(73)90210-0.

[3] [3]
Beckett, P. R.; Foster, R. W. Oxyfedrine — A partial agonist at β-adrenoceptors. European Journal of Pharmacology. 1972-11-01, 20 (2). ISSN 0014-2999. doi:10.1016/0014-2999(72)90145-8.

[pmid20326-4] [4]
Chichkanov, G. G.; Chumburidze, V. B. [Mechanism of the antianginal action of oxyfedrine]. Farmakologiia I Toksikologiia. 1977, 40 (3) [2024-05-09]. ISSN 0014-8318. PMID 20326. （原始内容存档于2024-06-14）.

[pmid1801897-5] [5]
Jc, Kaski; L, Araujo; A, Maseri. Effects of oxyfedrine on regional myocardial blood flow in patients with coronary artery disease. Cardiovascular drugs and therapy. 1991 Dec, 5 (6) [2024-05-09]. ISSN 0920-3206. PMID 1801897. doi:10.1007/BF00143526. （原始内容存档于2024-05-09）（英语）. 请检查|date=中的日期值 (帮助)

[pmid6117671-6] [6]
Chichkanov, G. G.; Bogolepov, A. K.; Matsievskiĭ, D. D. [Mechanism of the effect of anti-angina drugs with adrenergic beta receptor agonist action on the collateral hemodynamics and redistribution of the blood flow in chronic myocardial ischemia]. Kardiologiia. 1981-10, 21 (10). ISSN 0022-9040. PMID 6117671.

[pmid15802815-7] [7]
Mazumdar K, Dutta NK, Kumar KA, Dastidar SG. In vitro and in vivo synergism between tetracycline and the cardiovascular agent oxyfedrine HCl against common bacterial strains. Biological & Pharmaceutical Bulletin. April 2005, 28 (4): 713–7 [2024-05-09]. PMID 15802815. doi:10.1248/bpb.28.713 . （原始内容存档于2024-06-06）.

[8] [8]
Thiele Kurt, 美国专利第3,225,095号 (1965 to Degussa).

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