前脑啡黑细胞促素皮促素(Pro-opiomelanocortin),简称POMC,为一种由241个氨基酸组成的前驱多肽。POMC最初翻译且修饰前的型态称为原POMC(pre-POMC),含有285个氨基酸,原POMC移除信号肽之后才会成为POMC。
Quick Facts 鸦片黑皮质素原, 已知的结构 ...
鸦片黑皮质素原 |
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识别号 |
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别名 | POMC;, POC, proopiomelanocortin, OBAIRH, LPH, CLIP, ACTH, NPP, MSH |
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外部ID | OMIM:176830 MGI:97742 HomoloGene:723 GeneCards:POMC |
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为以下药物的标靶 |
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Opioid receptor delta 1、Opioid receptor, delta 1、opioid receptor kappa 1、Opioid receptor, kappa 1[1] |
黑素皮质素受体2[2] |
黑素皮质素受体3[3] |
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RNA表达模式 |
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查阅更多表达数据 |
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直系同源 |
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物种 | 人类 | 小鼠 |
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基因位置(UCSC) | Chr 2: 25.16 – 25.17 Mb | Chr 12: 4 – 4.01 Mb |
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PubMed查找 | [6] | [7] |
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维基数据 |
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Quick Facts Opioids neuropeptide, 鉴定 ...
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POMC可以切成多种多肽片段,每一个多肽片段都有由囊泡所包覆,并经由胞吐作用释放到细胞外液:
- 黑色素细胞刺激素(α-MSH):由弓状核的神经元产生的α-MSH,在调节食欲以及性行为中扮演重要角色。脑下垂体间叶分泌的α-MSH则调控黑色素的产生。
- 促肾上腺皮质激素(ACTH):属于肽类激素,负责调控糖皮质激素的分泌。
- β-内啡肽(β-Endorphin)及甲硫脑素(Met-enkephalin):属于内源性的类鸦片多肽,可于脑部多处作用。前者是脑内啡,后者是脑啡肽。会和中枢神经系统内的神经细胞,其细胞膜上的鸦片类受体 (Opioid receptors) 结合,达到镇痛的效果。
- Afamelanotide
- Melanocortin
- Melanotan II
- Millington GW. Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors. Clinical and Experimental Dermatology. May 2006, 31 (3): 407–12. PMID 16681590. doi:10.1111/j.1365-2230.2006.02128.x.
- Millington GW. The role of proopiomelanocortin (POMC) neurones in feeding behaviour. Nutrition & Metabolism. September 2007, 4: 18. PMC 2018708 . PMID 17764572. doi:10.1186/1743-7075-4-18.
- Bhardwaj RS, Luger TA. Proopiomelanocortin production by epidermal cells: evidence for an immune neuroendocrine network in the epidermis. Archives of Dermatological Research. 1994, 287 (1): 85–90. PMID 7726641. doi:10.1007/BF00370724.
- Raffin-Sanson ML, de Keyzer Y, Bertagna X. Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions. European Journal of Endocrinology. August 2003, 149 (2): 79–90. PMID 12887283. doi:10.1530/eje.0.1490079.
- Dores RM, Lecaude S. Trends in the evolution of the proopiomelanocortin gene. General and Comparative Endocrinology. May 2005, 142 (1-2): 81–93. PMID 15862552. doi:10.1016/j.ygcen.2005.02.003.
- König S, Luger TA, Scholzen TE. Monitoring neuropeptide-specific proteases: processing of the proopiomelanocortin peptides adrenocorticotropin and alpha-melanocyte-stimulating hormone in the skin. Experimental Dermatology. October 2006, 15 (10): 751–61. PMID 16984256. doi:10.1111/j.1600-0625.2006.00472.x.
- Farooqi S, O'Rahilly S. Genetics of obesity in humans. Endocrine Reviews. December 2006, 27 (7): 710–18. PMID 17122358. doi:10.1210/er.2006-0040.