Sp8转录因子

Sp8转录因子又称为特异性蛋白8（specificity protein 8、SP-8）或Btd转录因子^[5]是由SP8基因编码的人类蛋白质^[6][7]，位于人类的7号染色体中。Sp8是Sp/KLF家族的转录因子。

Sp8转录因子
识别号
别名	SP8；, BTD, Sp8 transcription factor
外部ID	OMIM：608306 MGI：2443471 HomoloGene：18548 GeneCards：SP8
基因位置（人类） 染色体 7号染色体[1] 基因座 7p21.1 起始 20,782,279 bp[1] 终止 20,786,886 bp[1]
基因位置（小鼠） 染色体 小鼠12号染色体[2] 基因座 12|12 F2 起始 118,810,064 bp[2] 终止 118,816,311 bp[2]
基因本体 分子功能 • DNA结合 • 金属离子结合 • nucleic acid binding • DNA-binding transcription factor activity, RNA polymerase II-specific 细胞组分 • 细胞核 生物学过程 • proximal/distal pattern formation • regulation of transcription, DNA-templated • dorsal/ventral pattern formation • embryonic limb morphogenesis • transcription, DNA-templated • regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	221833	320145
Ensembl	ENSG00000164651	ENSMUSG00000048562
UniProt	Q8IXZ3	Q8BMJ8
mRNA​序列	NM_182700 ​NM_198956	NM_177082 ​NM_001379379 ​NM_001379380
蛋白序列	NP_874359 ​NP_945194	NP_796056 ​NP_001366308 ​NP_001366309
基因位置​（UCSC）	Chr 7: 20.78 – 20.79 Mb	Chr 12: 118.81 – 118.82 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

功能

Sp8在肢体生长早起扮演了协调的作用。^[5]在小鼠实验中，若小鼠缺失Sp8基因会导致严重的脑外畸形（英语：Exencephaly）。^[8]

参考文献

1. GRCh38: Ensembl release 89: ENSG00000164651 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048562 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A. mBtd is required to maintain signaling during murine limb development (PDF). Genes & Development. November 2003, 17 (21): 2630–5 [2024-01-28]. PMC 280612 . PMID 14597661. doi:10.1101/gad.274103. （原始内容存档 (PDF)于2017-09-22）.
6. Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ. Sp8 is crucial for limb outgrowth and neuropore closure. Proceedings of the National Academy of Sciences of the United States of America. October 2003, 100 (21): 12195–200. PMC 218735 . PMID 14526104. doi:10.1073/pnas.2134310100 .
7. Entrez Gene: Sp8 transcription factor.
8. Waclaw RR, Allen ZJ, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K. The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons. Neuron. February 2006, 49 (4): 503–16. PMID 16476661. S2CID 17734218. doi:10.1016/j.neuron.2006.01.018 .

延伸阅读

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