CGP-7930

CGP-7930（化学名： 2,6-二叔丁基-4-(3-羟基-2,2-二甲基丙基)-苯酚，2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol）是一种有机化合物，是GABA_B受体的正向别构调节剂，其作用效果和其同系物BSPP类似^[1][2][3][4]。

CGP-7930

识别信息
IUPAC命名法 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol
CAS号	57717-80-3  Y
PubChem CID	5024764
IUPHAR/BPS	1079
ChemSpider	4203613 N
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID90407620
化学信息
化学式	C19H32O2
摩尔质量	292.46 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES CC(C)(C)c1cc(CC(C)(C)CO)cc(C(C)(C)C)c1O
InChI InChI=1S/C19H32O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,20-21H,11-12H2,1-8H3 N Key:XLWJPQQFJNGUPA-UHFFFAOYSA-N N

参考文献

1. Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, et al. Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501. Molecular Pharmacology. November 2001, 60 (5): 963–71. PMID 11641424.
2. Binet V, Brajon C, Le Corre L, Acher F, Pin JP, Prézeau L. The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor. The Journal of Biological Chemistry. July 2004, 279 (28): 29085–91. PMID 15126507. doi:10.1074/jbc.M400930200 .
3. Chen Y, Menendez-Roche N, Sher E. Differential modulation by the GABAB receptor allosteric potentiator 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area. The Journal of Pharmacology and Experimental Therapeutics. June 2006, 317 (3): 1170–7. PMID 16507713. doi:10.1124/jpet.105.099176.
4. Adams CL, Lawrence AJ. CGP7930: a positive allosteric modulator of the GABAB receptor. CNS Drug Reviews: 308–16. PMC 6494120 . PMID 17894647. doi:10.1111/j.1527-3458.2007.00021.x.

外部链接 

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