蛋白酪氨酸磷酸酶C型受体

蛋白酪氨酸磷酸酶C型受体（英语：Protein tyrosine phosphatase, receptor type, C，缩写：PTPRC）是一个由PTPRC人类基因编码的酶^[6] 蛋白酪氨酸磷酸酶C型受体又叫做45号分化簇抗原，以前曾叫白细胞常见抗原（英语：leukocyte common antigen，缩写：LCA）。^[7]

蛋白酪氨酸磷酸酶C型受体
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1YGU、​1YGR、​5FMV、​5FN6、​5FN7
识别号
别名	PTPRC；, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
外部ID	OMIM：151460 MGI：97810 HomoloGene：2126 GeneCards：PTPRC
相关疾病
溃疡性结肠炎[1]
基因位置（人类） 染色体 1号染色体[2] 基因座 1q31.3-q32.1 起始 198,638,457 bp[2] 终止 198,757,476 bp[2]
基因位置（小鼠） 染色体 小鼠1号染色体[3] 基因座 1 E4|1 60.73 cM 起始 137,990,599 bp[3] 终止 138,103,446 bp[3]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • phosphoprotein phosphatase activity • phosphatase activity • 血浆蛋白结合 • transmembrane receptor protein tyrosine phosphatase activity • protein kinase binding • 水解酶活性 • protein tyrosine phosphatase activity 细胞组分 • integral component of membrane • 膜 • 粘着斑 • 细胞膜 • integral component of plasma membrane • cell surface • 脂筏模型 • 外排体 • external side of plasma membrane • secretory granule membrane 生物学过程 • B cell receptor signaling pathway • cell cycle phase transition • release of sequestered calcium ion into cytosol • negative regulation of protein kinase activity • bone marrow development • stem cell development • 蛋白质去磷酸化 • negative regulation of cytokine-mediated signaling pathway • positive regulation of hematopoietic stem cell migration • regulation of cell cycle • negative regulation of cell adhesion involved in substrate-bound cell migration • negative regulation of T cell mediated cytotoxicity • cell surface receptor signaling pathway • B cell proliferation • T cell differentiation • positive regulation of B cell proliferation • defense response to virus • positive regulation of T cell proliferation • hematopoietic progenitor cell differentiation • positive regulation of antigen receptor-mediated signaling pathway • T cell receptor signaling pathway • positive regulation of stem cell proliferation • 去磷酸化 • positive regulation of protein kinase activity • peptidyl-tyrosine dephosphorylation • neutrophil degranulation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	5788	19264
Ensembl	ENSG00000081237 ​ENSG00000262418	ENSMUSG00000026395
UniProt	P08575	P06800
mRNA​序列	​NM_001267798 ​NM_002838 ​NM_080921 ​NM_080922	NM_001111316 ​NM_001268286 ​NM_011210
蛋白序列	NP_001254727 ​NP_002829 ​NP_563578 NP_563578.2 NP_002829.3	NP_001104786 ​NP_001255215 ​NP_035340
基因位置​（UCSC）	Chr 1: 198.64 – 198.76 Mb	Chr 1: 137.99 – 138.1 Mb
PubMed​查找	[4]	[5]
维基数据
查看/编辑人类 查看/编辑小鼠

参考文献

1. 與蛋白酪氨酸磷酸酶C型受體相關的疾病；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000081237、​ENSG00000262418 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000026395 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc. Natl. Acad. Sci. U.S.A. September 1990, 87 (18): 7000–4 [2019-05-01]. PMC 54670 . PMID 2169617. doi:10.1073/pnas.87.18.7000. （原始内容存档于2019-10-17）.
7. Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C. （原始内容存档于2010-12-05）.