组织蛋白酶W

组织蛋白酶W（英语：Cathepsin W）是一种在人体中由CTSW基因编码的蛋白质。^[5][6][7]

组织蛋白酶W
识别号
别名	CTSW；, LYPN, cathepsin W
外部ID	OMIM：602364 MGI：1338045 HomoloGene：37471 GeneCards：CTSW
基因位置（人类） 染色体 11号染色体[1] 基因座 11q13.1 起始 65,879,809 bp[1] 终止 65,883,741 bp[1]
基因位置（小鼠） 染色体 小鼠19号染色体[2] 基因座 19|19 A 起始 5,515,071 bp[2] 终止 5,518,535 bp[2]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • 肽酶活性 • cysteine-type endopeptidase activity • 半胱氨酸型肽酶活性 • 水解酶活性 细胞组分 • 溶酶体 • 膜 • platelet dense granule lumen • 细胞外区域 • 细胞外空间 • 内质网 生物学过程 • proteolysis involved in cellular protein catabolic process • 免疫反应 • 蛋白酶解 • platelet degranulation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	1521	13041
Ensembl	ENSG00000172543	ENSMUSG00000024910
UniProt	P56202	P56203
mRNA​序列	NM_001335	NM_009985
蛋白序列	NP_001326	NP_034115
基因位置​（UCSC）	Chr 11: 65.88 – 65.88 Mb	Chr 19: 5.52 – 5.52 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

该基因编码的蛋白质是半胱氨酸组织蛋白酶肽酶C1家族的成员，是一种半胱氨酸蛋白酶组织蛋白酶，可能在T细胞溶细胞活性的机制或调节中具有特定功能。编码的蛋白质被发现与自然杀伤细胞和细胞毒性T细胞的内质网内的细胞膜有关。该基因的表达被白细胞介素2上调。^[7]

参见

• 组织蛋白酶

参考文献

1. GRCh38: Ensembl release 89: ENSG00000172543 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024910 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Linnevers C, Smeekens SP, Brömme D. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. FEBS Lett. May 1997, 405 (3): 253–9. PMID 9108299. S2CID 45420314. doi:10.1016/S0014-5793(97)00118-X .
6. Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D. Genomic structure, chromosomal localization, and expression of human cathepsin W. Biochem Biophys Res Commun. Aug 1998, 248 (2): 255–61. PMID 9675123. doi:10.1006/bbrc.1998.8954.
7. Entrez Gene: CTSW cathepsin W.

阅读

• Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
• Meinhardt C, Peitz U, Treiber G, et al. Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene.. Biochem. Biophys. Res. Commun. 2004, 321 (4): 975–80. PMID 15358123. doi:10.1016/j.bbrc.2004.07.056.
• Zhang Z, Henzel WJ. Signal peptide prediction based on analysis of experimentally verified cleavage sites.. Protein Sci. 2005, 13 (10): 2819–24. PMC 2286551 . PMID 15340161. doi:10.1110/ps.04682504.
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
• Buhling F, Kellner U, Guenther D, et al. Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract.. Biol. Chem. 2003, 383 (7–8): 1285–9. PMID 12437118. S2CID 23389714. doi:10.1515/BC.2002.144.
• Wex T, Bühling F, Wex H, et al. Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum.. J. Immunol. 2001, 167 (4): 2172–8. PMID 11490002. doi:10.4049/jimmunol.167.4.2172 .
• Wex T, Levy B, Wex H, Brömme D. Human cathepsins W and F form a new subgroup of cathepsins that is evolutionary separated from the cathepsin B- and L-like cysteine proteases.. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 2000, 477: 271–80. ISBN 0-306-46383-0. PMID 10849754. doi:10.1007/0-306-46826-3_29.
• Brinkworth RI, Tort JF, Brindley PJ, Dalton JP. Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes.. Int. J. Biochem. Cell Biol. 2000, 32 (3): 373–84. PMID 10716634. doi:10.1016/S1357-2725(99)00129-6.
• Wex T, Levy B, Wex H, Brömme D. Human cathepsins F and W: A new subgroup of cathepsins.. Biochem. Biophys. Res. Commun. 1999, 259 (2): 401–7. PMID 10362521. doi:10.1006/bbrc.1999.0700.
• Brown J, Matutes E, Singleton A, et al. Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase.. Leukemia. 1998, 12 (11): 1771–81. PMID 9823953. doi:10.1038/sj.leu.2401164 .

外部链接

• The MEROPS online database for peptidases and their inhibitors: C01.037^{[失效链接]}