白细胞介素-6

白细胞介素6
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4O9H、1ALU、1IL6、1P9M、2IL6、4CNI、4J4L、4NI7、4NI9、4ZS7
识别号
别名	IL6；, BSF2, HGF, HSF, IFNB2, IL-6, BSF-2, CDF, IFN-beta-2, interleukin 6
外部ID	OMIM：147620 MGI：96559 HomoloGene：502 GeneCards：IL6
基因位置（人类）
染色体	7号染色体
终止	22,732,002 bp
基因位置（小鼠）
染色体	小鼠5号染色体
终止	30,224,979 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• 细胞因子活性; • 生长因子活性; • interleukin-6 receptor binding; • 血浆蛋白结合;
细胞组分	• 细胞外区域; • interleukin-6 receptor complex; • 细胞外空间; • endoplasmic reticulum lumen;
生物学过程	• regulation of angiogenesis; • positive regulation of translation; • platelet activation; • humoral immune response; • defense response to virus; • response to peptidoglycan; • neuron projection development; • defense response to Gram-positive bacterium; • negative regulation of fat cell differentiation; • positive regulation of peptidyl-serine phosphorylation; • positive regulation of leukocyte chemotaxis; • positive regulation of T cell proliferation; • positive regulation of interleukin-6 production; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of acute inflammatory response; • inflammatory response; • negative regulation of collagen biosynthetic process; • positive regulation of MAPK cascade; • hepatic immune response; • monocyte chemotaxis; • positive regulation of DNA-binding transcription factor activity; • negative regulation of apoptotic process; • positive regulation of osteoblast differentiation; • positive regulation of NF-kappaB transcription factor activity; • 急性期反应; • 免疫反应; • regulation of vascular endothelial growth factor production; • positive regulation of chemokine production; • negative regulation of lipid storage; • neutrophil mediated immunity; • positive regulation of smooth muscle cell proliferation; • positive regulation of type B pancreatic cell apoptotic process; • response to glucocorticoid; • defense response to Gram-negative bacterium; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • positive regulation of B cell activation; • 翻译后修饰; • regulation of signaling receptor activity; • positive regulation of tyrosine phosphorylation of STAT protein; • neutrophil apoptotic process; • negative regulation of cell population proliferation; • positive regulation of gene expression; • endocrine pancreas development; • negative regulation of bone resorption; • positive regulation of transcription, DNA-templated; • positive regulation of transcription by RNA polymerase II; • glucagon secretion; • cellular response to hydrogen peroxide; • cellular response to lipopolysaccharide; • T-helper 17 cell lineage commitment; • positive regulation of T-helper 2 cell cytokine production; • negative regulation of interleukin-1-mediated signaling pathway; • cytokine-mediated signaling pathway; • interleukin-6-mediated signaling pathway; • positive regulation of receptor signaling pathway via JAK-STAT; • 信号转导;
	Sources:Amigo / QuickGO
直系同源
	3569
	16193
	ENSG00000136244
	ENSMUSG00000025746
	P05231
	P08505
	NM_000600; NM_001318095; NM_001371096
	NM_031168; NM_001314054
	NP_000591; NP_001305024; NP_001358025
	NP_001300983; NP_112445
	维基数据
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白细胞介素-6（Interleukin 6），简称白介素-6（IL-6，在人体内由IL6基因编码^[5]），最初由日本免疫学家岸本忠三团队发现^[6]，是一种介导炎症的白细胞介素（但在某些情况下也具有抗炎症作用）^[7]^[5]。白细胞介素-6可由T细胞、B细胞、单核细胞、成纤维细胞、角质形成细胞、内皮细胞、系膜细胞（英语：mesangial cell），以及一部分肿瘤细胞分泌^[8]。