抑癌蛋白M

抑癌蛋白M（英语：Oncostatin M，缩写OSM，也译作制癌蛋白M、抑瘤素M）是由人类基因 OSM 编码的蛋白质^[5]，由209个氨基酸残基组成。OSM是一种多效的细胞因子，属于IL-6家族^[6]，和白血病抑制因子（LIF）在结构和功能上类似^[6]，在肝脏发育、造血作用、炎症反应以及中枢神经系统发育和骨形成中有重要作用^[7]。

OSM
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1EVS
识别号
别名	OSM；, Osm, OncoM, oncostatin M
外部ID	OMIM：165095 MGI：104749 HomoloGene：10741 GeneCards：OSM
基因位置（人类） 染色体 22号染色体[1] 基因座 22q12.2 起始 30,262,829 bp[1] 终止 30,266,851 bp[1]
基因位置（小鼠） 染色体 小鼠11号染色体[2] 基因座 11 A1|11 2.94 cM 起始 4,186,420 bp[2] 终止 4,191,026 bp[2]
基因本体 分子功能 • 细胞因子活性 • oncostatin-M receptor binding • 生长因子活性 细胞组分 • 细胞外区域 • 细胞外空间 生物学过程 • oncostatin-M-mediated signaling pathway • positive regulation of peptidyl-serine phosphorylation • multicellular organism development • 免疫反应 • positive regulation of cell population proliferation • positive regulation of acute inflammatory response • regulation of growth • 细胞增殖 • negative regulation of hormone secretion • positive regulation of cell division • positive regulation of MAPK cascade • negative regulation of cell population proliferation • positive regulation of transcription by RNA polymerase II • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • positive regulation of peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of inflammatory response • positive regulation of protein kinase B signaling • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	5008	18413
Ensembl	ENSG00000099985	ENSMUSG00000058755
UniProt	P13725	P53347
mRNA​序列	NM_020530 ​NM_001319108	NM_001013365
蛋白序列	NP_001306037 ​NP_065391	NP_001013383
基因位置​（UCSC）	Chr 22: 30.26 – 30.27 Mb	Chr 11: 4.19 – 4.19 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

参考文献

1. GRCh38: Ensembl release 89: ENSG00000099985 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058755 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rose TM, Bruce AG. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Natl. Acad. Sci. U.S.A. October 1991, 88 (19): 8641–5. PMC 52565 . PMID 1717982. doi:10.1073/pnas.88.19.8641.
6. Tanaka M, Miyajima A. Oncostatin M, a multifunctional cytokine. Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 2003, 149: 39–52. ISBN 978-3-540-20213-4. PMID 12811586. doi:10.1007/s10254-003-0013-1.
7. Walker EC, McGregor NE, Poulton IJ, Solano M, Pompolo S, Fernandes TJ, Constable MJ, Nicholson GC, Zhang JG, Nicola NA, Gillespie MT, Martin TJ, Sims NA. Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest. 2010, 120 (2): 582–92 [2019-12-09]. PMC 2810087 . PMID 20051625. doi:10.1172/JCI40568. （原始内容存档于2020-05-29）. 简明摘要 – ScienceDaily.

延伸阅读

• Schieven GL, Kallestad JC, Brown TJ, Ledbetter JA, Linsley PS. Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase. J. Immunol. September 1992, 149 (5): 1676–82. PMID 1324279.
• Hermanns HM, Radtke S, Schaper F, Heinrich PC, Behrmann I. Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to the oncostatin M receptor. J. Biol. Chem. December 2000, 275 (52): 40742–8. PMID 11016927. doi:10.1074/jbc.M005408200.

外部链接

• 医学主题词表（MeSH）：Oncostatin+M