圣地亚哥省（西班牙语：Provincia de Santiago）是智利圣地亚哥首都大区的一个省，总面积2109.7平方公里。总人口4728,443，人口密度2241.3人/平方公里。圣地亚哥省包含32个市镇。圣地亚哥省的产值占全国的30%。该省为大陆性气候，年降水量367毫米。
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