四膜虫醇合酶(英语:Tetrahymanol synthase,或称作鲨烯-四膜虫醇环化酶,squalene-tetrahymanol cyclase,EC 4.2.1.123)是一种最早分离自四膜虫的一种酶,催化链状三萜鲨烯生成五环三萜四膜虫醇的反应,该反应可逆[1][2]:
- 鲨烯 + H2O
四膜虫醇
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Saar J, Kader JC, Poralla K, Ourisson G. Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila. Biochimica et Biophysica Acta. September 1991, 1075 (1): 93–101. PMID 1892870. doi:10.1016/0304-4165(91)90080-z.
Giner JL, Rocchetti S, Neunlist S, Rohmer M, Arigoni D. Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis. Chemical Communications. June 2005, 的 (24): 3089–91. PMID 15959594. doi:10.1039/b504300j.